Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive p...

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Bibliographic Details
Published in:	Oncotarget Vol. 8; no. 28; p. 46663
Main Authors:	Koleini, Navid, Kardami, Elissavet
Format:	Journal Article
Language:	English
Published:	United States 11.07.2017
Subjects:	Animals Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - therapeutic use Autophagy - drug effects Biomarkers Cardiotoxicity - diagnosis Cardiotoxicity - etiology Cardiotoxicity - metabolism Doxorubicin - adverse effects Doxorubicin - therapeutic use Heart Diseases - diagnosis Heart Diseases - etiology Heart Diseases - metabolism Humans Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondrial Degradation - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Signal Transduction - drug effects lysosomal dysfunction heart failure anthracyclines impaired autophagy and mitophagy oncocardiology
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
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