Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive p...

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Bibliographic Details
Published in:Oncotarget Vol. 8; no. 28; p. 46663
Main Authors: Koleini, Navid, Kardami, Elissavet
Format: Journal Article
Language:English
Published: United States 11.07.2017
Subjects:
Animals
Antibiotics, Antineoplastic - adverse effects
Antibiotics, Antineoplastic - therapeutic use
Autophagy - drug effects
Biomarkers
Cardiotoxicity - diagnosis
Cardiotoxicity - etiology
Cardiotoxicity - metabolism
Doxorubicin - adverse effects
Doxorubicin - therapeutic use
Heart Diseases - diagnosis
Heart Diseases - etiology
Heart Diseases - metabolism
Humans
Mitochondria, Heart - drug effects
Mitochondria, Heart - metabolism
Mitochondrial Degradation - drug effects
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Signal Transduction - drug effects
lysosomal dysfunction
heart failure
anthracyclines
impaired autophagy and mitophagy
oncocardiology
ISSN:1949-2553, 1949-2553
Online Access:Get more information
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Summary:Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive picture has yet to emerge. Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. Autophagic cell death has been described, and has been proposed to contribute to Dox-cardiotoxicity. Additionally, mitophagy, autophagic removal of damaged mitochondria, is affected by Dox in a manner contributing to toxicity. Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes.
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ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.16944