Identification of Potential Hub Genes and miRNA-mRNA Pairs Related to the Progression and Prognosis of Cervical Cancer Through Integrated Bioinformatics Analysis
In recent years, the incidence and mortality of cervical cancer have increased worldwide. At the same time, increasing data have confirmed that miRNA-mRNA plays a positive or negative regulatory role in many cancers. This study attempted to screen effective miRNA-mRNA in the progression of cervical...
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| Veröffentlicht in: | Frontiers in genetics Jg. 12; S. 775006 |
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| Abstract | In recent years, the incidence and mortality of cervical cancer have increased worldwide. At the same time, increasing data have confirmed that miRNA-mRNA plays a positive or negative regulatory role in many cancers. This study attempted to screen effective miRNA-mRNA in the progression of cervical cancer, and to study the mechanism of miRNA-mRNA in the progression of cervical cancer. The expression profile data of GSE7410, GSE 63514, GSE 86100 and TCGA-CESC were downloaded, and 34 overlapping differentially expressed genes (22 up-regulated and 12 down-regulated) and 166 miRNAs (74 down-regulated and 92 up-regulated) were screened through limma package. Then, miR-197-3p/TYMS pairs were obtained by PPI, functional enrichment, Kaplan-Meier plotter analysis, Cox univariate and multivariate analysis, risk modeling, WGCNA, qPCR and dual-luciferase experiments. The results showed that TYMS was an independent prognostic factor of cervical cancer, and its expression level was negatively correlated with cervical cancer tissue grade (TMN), tumor grade, age, microsatellite stability and tumor mutation load, and positively correlated with methyl expression in DNMT1, DNMT2, DNMT3A and DNMT3B. Functional experiments showed that TYMS knockout could promote the proliferation, migration and invasion of HeLa cells and reduce apoptosis. Overexpression of TYMS showed the opposite trend, miR-197-3p was negatively correlated with the expression of TYMS. MiR-197-3p inhibitor reversed the effect of si-TYMS on the proliferation of HeLa cells. In conclusion, these results reveal that TYMS plays a very important role in the prognosis and progression of cervical cancer, and has the potential to be thought of as cervical cancer biomarkers. At the same time, miR-197-3p/TYMS axis can regulate the deterioration of cervical cancer cells, which lays a foundation for the molecular diagnosis and treatment of cervical cancer. |
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| AbstractList | In recent years, the incidence and mortality of cervical cancer have increased worldwide. At the same time, increasing data have confirmed that miRNA-mRNA plays a positive or negative regulatory role in many cancers. This study attempted to screen effective miRNA-mRNA in the progression of cervical cancer, and to study the mechanism of miRNA-mRNA in the progression of cervical cancer. The expression profile data of GSE7410, GSE 63514, GSE 86100 and TCGA-CESC were downloaded, and 34 overlapping differentially expressed genes (22 up-regulated and 12 down-regulated) and 166 miRNAs (74 down-regulated and 92 up-regulated) were screened through limma package. Then, miR-197-3p/TYMS pairs were obtained by PPI, functional enrichment, Kaplan-Meier plotter analysis, Cox univariate and multivariate analysis, risk modeling, WGCNA, qPCR and dual-luciferase experiments. The results showed that TYMS was an independent prognostic factor of cervical cancer, and its expression level was negatively correlated with cervical cancer tissue grade (TMN), tumor grade, age, microsatellite stability and tumor mutation load, and positively correlated with methyl expression in DNMT1, DNMT2, DNMT3A and DNMT3B. Functional experiments showed that TYMS knockout could promote the proliferation, migration and invasion of HeLa cells and reduce apoptosis. Overexpression of TYMS showed the opposite trend, miR-197-3p was negatively correlated with the expression of TYMS. MiR-197-3p inhibitor reversed the effect of si-TYMS on the proliferation of HeLa cells. In conclusion, these results reveal that TYMS plays a very important role in the prognosis and progression of cervical cancer, and has the potential to be thought of as cervical cancer biomarkers. At the same time, miR-197-3p/TYMS axis can regulate the deterioration of cervical cancer cells, which lays a foundation for the molecular diagnosis and treatment of cervical cancer. In recent years, the incidence and mortality of cervical cancer have increased worldwide. At the same time, increasing data have confirmed that miRNA-mRNA plays a positive or negative regulatory role in many cancers. This study attempted to screen effective miRNA-mRNA in the progression of cervical cancer, and to study the mechanism of miRNA-mRNA in the progression of cervical cancer. The expression profile data of GSE7410, GSE 63514, GSE 86100 and TCGA-CESC were downloaded, and 34 overlapping differentially expressed genes (22 up-regulated and 12 down-regulated) and 166 miRNAs (74 down-regulated and 92 up-regulated) were screened through limma package. Then, miR-197-3p/TYMS pairs were obtained by PPI, functional enrichment, Kaplan-Meier plotter analysis, Cox univariate and multivariate analysis, risk modeling, WGCNA, qPCR and dual-luciferase experiments. The results showed that TYMS was an independent prognostic factor of cervical cancer, and its expression level was negatively correlated with cervical cancer tissue grade (TMN), tumor grade, age, microsatellite stability and tumor mutation load, and positively correlated with methyl expression in DNMT1, DNMT2, DNMT3A and DNMT3B. Functional experiments showed that TYMS knockout could promote the proliferation, migration and invasion of HeLa cells and reduce apoptosis. Overexpression of TYMS showed the opposite trend, miR-197-3p was negatively correlated with the expression of TYMS. MiR-197-3p inhibitor reversed the effect of si-TYMS on the proliferation of HeLa cells. In conclusion, these results reveal that TYMS plays a very important role in the prognosis and progression of cervical cancer, and has the potential to be thought of as cervical cancer biomarkers. At the same time, miR-197-3p/TYMS axis can regulate the deterioration of cervical cancer cells, which lays a foundation for the molecular diagnosis and treatment of cervical cancer.In recent years, the incidence and mortality of cervical cancer have increased worldwide. At the same time, increasing data have confirmed that miRNA-mRNA plays a positive or negative regulatory role in many cancers. This study attempted to screen effective miRNA-mRNA in the progression of cervical cancer, and to study the mechanism of miRNA-mRNA in the progression of cervical cancer. The expression profile data of GSE7410, GSE 63514, GSE 86100 and TCGA-CESC were downloaded, and 34 overlapping differentially expressed genes (22 up-regulated and 12 down-regulated) and 166 miRNAs (74 down-regulated and 92 up-regulated) were screened through limma package. Then, miR-197-3p/TYMS pairs were obtained by PPI, functional enrichment, Kaplan-Meier plotter analysis, Cox univariate and multivariate analysis, risk modeling, WGCNA, qPCR and dual-luciferase experiments. The results showed that TYMS was an independent prognostic factor of cervical cancer, and its expression level was negatively correlated with cervical cancer tissue grade (TMN), tumor grade, age, microsatellite stability and tumor mutation load, and positively correlated with methyl expression in DNMT1, DNMT2, DNMT3A and DNMT3B. Functional experiments showed that TYMS knockout could promote the proliferation, migration and invasion of HeLa cells and reduce apoptosis. Overexpression of TYMS showed the opposite trend, miR-197-3p was negatively correlated with the expression of TYMS. MiR-197-3p inhibitor reversed the effect of si-TYMS on the proliferation of HeLa cells. In conclusion, these results reveal that TYMS plays a very important role in the prognosis and progression of cervical cancer, and has the potential to be thought of as cervical cancer biomarkers. At the same time, miR-197-3p/TYMS axis can regulate the deterioration of cervical cancer cells, which lays a foundation for the molecular diagnosis and treatment of cervical cancer. |
| Author | Fu, Mingxu Cheng, Jiajing Jiang, Huici Qin, Jinlong Pei, Yongyan Lu, Fang Bi, Yingying |
| AuthorAffiliation | 2 School of Medicine and Chemical Engineering, Guangdong Pharmaceutical University , Guangzhou , China 1 Department of Obstetrics and Gynecology, Shanghai Fourth People ’s Hospital, School of Medicine, Tongji University , Shanghai , China |
| AuthorAffiliation_xml | – name: 2 School of Medicine and Chemical Engineering, Guangdong Pharmaceutical University , Guangzhou , China – name: 1 Department of Obstetrics and Gynecology, Shanghai Fourth People ’s Hospital, School of Medicine, Tongji University , Shanghai , China |
| Author_xml | – sequence: 1 givenname: Mingxu surname: Fu fullname: Fu, Mingxu – sequence: 2 givenname: Yongyan surname: Pei fullname: Pei, Yongyan – sequence: 3 givenname: Fang surname: Lu fullname: Lu, Fang – sequence: 4 givenname: Huici surname: Jiang fullname: Jiang, Huici – sequence: 5 givenname: Yingying surname: Bi fullname: Bi, Yingying – sequence: 6 givenname: Jiajing surname: Cheng fullname: Cheng, Jiajing – sequence: 7 givenname: Jinlong surname: Qin fullname: Qin, Jinlong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35003215$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3390/molecules25010228 10.1038/s41598-018-38017-0 10.1016/j.ygyno.2007.11.024 10.1186/s12876-016-0561-x 10.1016/j.canlet.2019.11.039 10.7150/thno.42096 10.1371/journal.pone.0164701 10.1016/j.jid.2019.05.011 10.1186/s12957-020-01881-0 10.7150/ijbs.42019 10.1016/j.cell.2018.03.042 10.1038/s41416-020-0831-9 10.1002/jgm.3257 10.1073/pnas.1509322112 10.1016/s2214-109x(20)30459-9 10.1002/jcp.28957 10.3389/fgene.2020.00478 10.1016/j.biopha.2020.110569 10.1007/978-1-4939-3578-9_5 10.1155/2020/8283401 10.1371/journal.pone.0234834 10.1038/s41568-020-0253-2 10.3389/fonc.2020.00809 10.1016/j.wneu.2020.02.159 10.3892/ijmm.2020.4684 10.1042/BSR20200980 10.18388/abp.2017_2338 10.1038/s41568-020-0290-x 10.3892/ol.2018.9848 10.18632/oncotarget.3107 10.1007/s13205-020-02362-7 10.1038/s41568-020-00306-0 10.1002/gcc.20577 10.1097/MD.0000000000018487 10.2147/CIA.S269171 10.1016/j.ypmed.2019.105902 10.1038/s41585-019-0211-5 10.2174/1871520620666200224093301 10.1016/j.cellsig.2020.109669 10.1002/ijc.33115 |
| ContentType | Journal Article |
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| Keywords | miR-197-3p/TYMS apoptosis proliferation cervical cancer invasion and migration |
| Language | English |
| License | Copyright © 2021 Fu, Pei, Lu, Jiang, Bi, Cheng and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Nana Jin, Codex Genetics Limited, Hong Kong SAR, China Edited by: Ramkrishna Mitra, Thomas Jefferson University, United States These authors have contributed equally to this work Nicola Mosca, UOC di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy Somnath Tagore, Columbia University, United States This article was submitted to RNA, a section of the journal Frontiers in Genetics |
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| SubjectTerms | apoptosis cervical cancer Genetics invasion and migration miR-197-3p/TYMS proliferation |
| Title | Identification of Potential Hub Genes and miRNA-mRNA Pairs Related to the Progression and Prognosis of Cervical Cancer Through Integrated Bioinformatics Analysis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35003215 https://www.proquest.com/docview/2618513956 https://pubmed.ncbi.nlm.nih.gov/PMC8727538 https://doaj.org/article/ea9b532f0f0b41028c6a8f10acf5c7e0 |
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