Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD

Acute graft-vs.-host (GVHD) disease remains a common complication of allogeneic stem cell transplantation with very poor outcomes once the disease becomes steroid refractory. Mesenchymal stem cells (MSCs) represent a promising therapeutic approach for the treatment of GVHD, but so far this strategy...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 12; p. 631353
Main Authors:	Mendt, Mayela, Daher, May, Basar, Rafet, Shanley, Mayra, Kumar, Bijender, Wei Inng, Francesca Lim, Acharya, Sunil, Shaim, Hila, Fowlkes, Natalie, Tran, Jamie P., Gokdemir, Elif, Uprety, Nadima, Nunez-Cortes, Ana K., Ensley, Emily, Mai, Thao, Kerbauy, Lucila N., Melo-Garcia, Luciana, Lin, Paul, Shen, Yifei, Mohanty, Vakul, Lu, JunJun, Li, Sufang, Nandivada, Vandana, Wang, Jing, Banerjee, Pinaki, Reyes-Silva, Francia, Liu, Enli, Ang, Sonny, Gilbert, April, Li, Ye, Wan, Xinhai, Gu, Jun, Zhao, Ming, Baran, Natalia, Muniz-Feliciano, Luis, Wilson, Jeffrey, Kaur, Indreshpal, Gagea, Mihai, Konopleva, Marina, Marin, David, Tang, Guilin, Chen, Ken, Champlin, Richard, Rezvani, Katayoun, Shpall, Elizabeth J.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 04.05.2021
Subjects:	Animals cell therapy Cellular Reprogramming - drug effects Cellular Reprogramming - immunology Cellular Reprogramming - physiology Cellular Reprogramming Techniques - methods Cytokines - pharmacology Female Fetal Blood - cytology Graft vs Host Disease - prevention & control GvHD Hematopoietic Stem Cell Transplantation Immunology Mesenchymal Stem Cell Transplantation mesenchymal stem cells Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - metabolism metabolic reprogramming Mice Mice, Inbred NOD priming Quality Control umbilical cord tissue priming GvHD umbilical cord tissue cell therapy mesenchymal stem cells metabolic reprogramming
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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