Robust Multi-TE ASL-Based Blood–Brain Barrier Integrity Measurements
Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood–tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood–brain barrier (BBB) integrit...
Uloženo v:
| Vydáno v: | Frontiers in neuroscience Ročník 15; s. 719676 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Switzerland
Frontiers Media S.A
03.12.2021
|
| Témata: | |
| ISSN: | 1662-453X, 1662-4548, 1662-453X |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood–tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood–brain barrier (BBB) integrity based on a test-retest analysis. This includes a novel scan protocol and an extension of the two-compartment model with an “intra-voxel transit time” (ITT) to address tissue transit effects. With the extended model, we intend to separate the underlying two distinct mechanisms of tissue transit and exchange. The performance of the extended model in comparison with the two-compartment model was evaluated in simulations. Multi-TE ASL sequence with two different bolus durations was used to acquire
in vivo
data (
n
= 10). Cerebral blood flow (CBF), arterial transit time (ATT) and Texch were fitted with the two models, and mean grey matter values were compared. Additionally, the extended model also extracted ITT parameter. The test-retest reliability of Texch was assessed for intra-session, inter-session and inter-visit pairs of measurements. Intra-class correlation coefficient (ICC) and within-subject coefficient of variance (CoV) for grey matter were computed to assess the precision of the method. Mean grey matter Texch and ITT values were found to be 227.9 ± 37.9 ms and 310.3 ± 52.9 ms, respectively. Texch estimated by the extended model was 32.6 ± 5.9% lower than the two-compartment model. A significant ICC was observed for all three measures of Texch reliability (
P
< 0.05). Texch intra-session CoV, inter-session CoV and inter-visit CoV were found to be 6.6%, 7.9%, and 8.4%, respectively. With the described improvements addressing intra-voxel transit effects, multi-TE ASL shows good reproducibility as a non-invasive measure of BBB permeability. These findings offer an encouraging step forward to apply this potential BBB permeability biomarker in clinical research. |
|---|---|
| AbstractList | Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood-tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood-brain barrier (BBB) integrity based on a test-retest analysis. This includes a novel scan protocol and an extension of the two-compartment model with an "intra-voxel transit time" (ITT) to address tissue transit effects. With the extended model, we intend to separate the underlying two distinct mechanisms of tissue transit and exchange. The performance of the extended model in comparison with the two-compartment model was evaluated in simulations. Multi-TE ASL sequence with two different bolus durations was used to acquire
data (
= 10). Cerebral blood flow (CBF), arterial transit time (ATT) and Texch were fitted with the two models, and mean grey matter values were compared. Additionally, the extended model also extracted ITT parameter. The test-retest reliability of Texch was assessed for intra-session, inter-session and inter-visit pairs of measurements. Intra-class correlation coefficient (ICC) and within-subject coefficient of variance (CoV) for grey matter were computed to assess the precision of the method. Mean grey matter Texch and ITT values were found to be 227.9 ± 37.9 ms and 310.3 ± 52.9 ms, respectively. Texch estimated by the extended model was 32.6 ± 5.9% lower than the two-compartment model. A significant ICC was observed for all three measures of Texch reliability (
< 0.05). Texch intra-session CoV, inter-session CoV and inter-visit CoV were found to be 6.6%, 7.9%, and 8.4%, respectively. With the described improvements addressing intra-voxel transit effects, multi-TE ASL shows good reproducibility as a non-invasive measure of BBB permeability. These findings offer an encouraging step forward to apply this potential BBB permeability biomarker in clinical research. Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood–tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood–brain barrier (BBB) integrity based on a test-retest analysis. This includes a novel scan protocol and an extension of the two-compartment model with an “intra-voxel transit time” (ITT) to address tissue transit effects. With the extended model, we intend to separate the underlying two distinct mechanisms of tissue transit and exchange. The performance of the extended model in comparison with the two-compartment model was evaluated in simulations. Multi-TE ASL sequence with two different bolus durations was used to acquire in vivo data ( n = 10). Cerebral blood flow (CBF), arterial transit time (ATT) and Texch were fitted with the two models, and mean grey matter values were compared. Additionally, the extended model also extracted ITT parameter. The test-retest reliability of Texch was assessed for intra-session, inter-session and inter-visit pairs of measurements. Intra-class correlation coefficient (ICC) and within-subject coefficient of variance (CoV) for grey matter were computed to assess the precision of the method. Mean grey matter Texch and ITT values were found to be 227.9 ± 37.9 ms and 310.3 ± 52.9 ms, respectively. Texch estimated by the extended model was 32.6 ± 5.9% lower than the two-compartment model. A significant ICC was observed for all three measures of Texch reliability ( P < 0.05). Texch intra-session CoV, inter-session CoV and inter-visit CoV were found to be 6.6%, 7.9%, and 8.4%, respectively. With the described improvements addressing intra-voxel transit effects, multi-TE ASL shows good reproducibility as a non-invasive measure of BBB permeability. These findings offer an encouraging step forward to apply this potential BBB permeability biomarker in clinical research. Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood–tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood–brain barrier (BBB) integrity based on a test-retest analysis. This includes a novel scan protocol and an extension of the two-compartment model with an “intra-voxel transit time” (ITT) to address tissue transit effects. With the extended model, we intend to separate the underlying two distinct mechanisms of tissue transit and exchange. The performance of the extended model in comparison with the two-compartment model was evaluated in simulations. Multi-TE ASL sequence with two different bolus durations was used to acquire in vivo data (n = 10). Cerebral blood flow (CBF), arterial transit time (ATT) and Texch were fitted with the two models, and mean grey matter values were compared. Additionally, the extended model also extracted ITT parameter. The test-retest reliability of Texch was assessed for intra-session, inter-session and inter-visit pairs of measurements. Intra-class correlation coefficient (ICC) and within-subject coefficient of variance (CoV) for grey matter were computed to assess the precision of the method. Mean grey matter Texch and ITT values were found to be 227.9 ± 37.9 ms and 310.3 ± 52.9 ms, respectively. Texch estimated by the extended model was 32.6 ± 5.9% lower than the two-compartment model. A significant ICC was observed for all three measures of Texch reliability (P < 0.05). Texch intra-session CoV, inter-session CoV and inter-visit CoV were found to be 6.6%, 7.9%, and 8.4%, respectively. With the described improvements addressing intra-voxel transit effects, multi-TE ASL shows good reproducibility as a non-invasive measure of BBB permeability. These findings offer an encouraging step forward to apply this potential BBB permeability biomarker in clinical research. Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood-tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood-brain barrier (BBB) integrity based on a test-retest analysis. This includes a novel scan protocol and an extension of the two-compartment model with an "intra-voxel transit time" (ITT) to address tissue transit effects. With the extended model, we intend to separate the underlying two distinct mechanisms of tissue transit and exchange. The performance of the extended model in comparison with the two-compartment model was evaluated in simulations. Multi-TE ASL sequence with two different bolus durations was used to acquire in vivo data (n = 10). Cerebral blood flow (CBF), arterial transit time (ATT) and Texch were fitted with the two models, and mean grey matter values were compared. Additionally, the extended model also extracted ITT parameter. The test-retest reliability of Texch was assessed for intra-session, inter-session and inter-visit pairs of measurements. Intra-class correlation coefficient (ICC) and within-subject coefficient of variance (CoV) for grey matter were computed to assess the precision of the method. Mean grey matter Texch and ITT values were found to be 227.9 ± 37.9 ms and 310.3 ± 52.9 ms, respectively. Texch estimated by the extended model was 32.6 ± 5.9% lower than the two-compartment model. A significant ICC was observed for all three measures of Texch reliability (P < 0.05). Texch intra-session CoV, inter-session CoV and inter-visit CoV were found to be 6.6%, 7.9%, and 8.4%, respectively. With the described improvements addressing intra-voxel transit effects, multi-TE ASL shows good reproducibility as a non-invasive measure of BBB permeability. These findings offer an encouraging step forward to apply this potential BBB permeability biomarker in clinical research.Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood-tissue exchange dynamics by probing the T2 relaxation of the labelled spins. In this study, we provide a recipe for robust assessment of exchange time (Texch) as a proxy measure of blood-brain barrier (BBB) integrity based on a test-retest analysis. This includes a novel scan protocol and an extension of the two-compartment model with an "intra-voxel transit time" (ITT) to address tissue transit effects. With the extended model, we intend to separate the underlying two distinct mechanisms of tissue transit and exchange. The performance of the extended model in comparison with the two-compartment model was evaluated in simulations. Multi-TE ASL sequence with two different bolus durations was used to acquire in vivo data (n = 10). Cerebral blood flow (CBF), arterial transit time (ATT) and Texch were fitted with the two models, and mean grey matter values were compared. Additionally, the extended model also extracted ITT parameter. The test-retest reliability of Texch was assessed for intra-session, inter-session and inter-visit pairs of measurements. Intra-class correlation coefficient (ICC) and within-subject coefficient of variance (CoV) for grey matter were computed to assess the precision of the method. Mean grey matter Texch and ITT values were found to be 227.9 ± 37.9 ms and 310.3 ± 52.9 ms, respectively. Texch estimated by the extended model was 32.6 ± 5.9% lower than the two-compartment model. A significant ICC was observed for all three measures of Texch reliability (P < 0.05). Texch intra-session CoV, inter-session CoV and inter-visit CoV were found to be 6.6%, 7.9%, and 8.4%, respectively. With the described improvements addressing intra-voxel transit effects, multi-TE ASL shows good reproducibility as a non-invasive measure of BBB permeability. These findings offer an encouraging step forward to apply this potential BBB permeability biomarker in clinical research. |
| Author | Chappell, Michael Buck, Mareike Alicja Günther, Matthias Mutsaerts, Henk J. M. M. Breutigam, Nora-Josefin Craig, Martin Huber, Jörn Mahroo, Amnah |
| AuthorAffiliation | 5 Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham , Nottingham , United Kingdom 4 Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham , Nottingham , United Kingdom 8 mediri GmbH , Heidelberg , Germany 3 Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center , Amsterdam , Netherlands 2 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany 1 MR Physics, Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany 6 Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford , United Kingdom 7 Nottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham , Nottingham , United Kingdom |
| AuthorAffiliation_xml | – name: 4 Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham , Nottingham , United Kingdom – name: 2 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany – name: 3 Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center , Amsterdam , Netherlands – name: 7 Nottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham , Nottingham , United Kingdom – name: 1 MR Physics, Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany – name: 8 mediri GmbH , Heidelberg , Germany – name: 5 Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham , Nottingham , United Kingdom – name: 6 Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford , United Kingdom |
| Author_xml | – sequence: 1 givenname: Amnah surname: Mahroo fullname: Mahroo, Amnah – sequence: 2 givenname: Mareike Alicja surname: Buck fullname: Buck, Mareike Alicja – sequence: 3 givenname: Jörn surname: Huber fullname: Huber, Jörn – sequence: 4 givenname: Nora-Josefin surname: Breutigam fullname: Breutigam, Nora-Josefin – sequence: 5 givenname: Henk J. M. M. surname: Mutsaerts fullname: Mutsaerts, Henk J. M. M. – sequence: 6 givenname: Martin surname: Craig fullname: Craig, Martin – sequence: 7 givenname: Michael surname: Chappell fullname: Chappell, Michael – sequence: 8 givenname: Matthias surname: Günther fullname: Günther, Matthias |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34924924$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kd9qFDEYxYNU7B99AG9kLr2ZNclkJpMboVtau7BF0ArehW--JGvK7KQmmULvfAff0CfpTLeVVhAC-UjO-Z2Ec0j2hjBYQt4yuqiqVn1wgx_SglPOFpKpRjYvyAFrGl6Kuvq-92TeJ4cpXVHa8FbwV2S_EorP64CcfQndmHJxMfbZl5enxfHXdbmEZE2x7EMwf379XkbwQ7GEGL2NxWrIdhN9vi0uLKQx2q0dcnpNXjrok33zsB-Rb2enlyfn5frzp9XJ8bpE0dS5NK6TaBSnyqHhrgMBwAQicmeqaWSNbHlXKcmMEhUVgNxYQNehcwYUrY7Iasc1Aa70dfRbiLc6gNf3ByFuNMTssbdaSSuQWgTTtkJC19YItAVExRiqrp5YH3es67HbWoPTPyL0z6DPbwb_Q2_CjW6nV1I5A94_AGL4OdqU9dYntH0Pgw1j0rxhnArR1nKSvnua9TfksYhJIHcCjCGlaJ1GnyH7MEf7XjOq58r1feV6rlzvKp-c7B_nI_z_njtRqrNw |
| CitedBy_id | crossref_primary_10_1002_epi4_12994 crossref_primary_10_1007_s10334_023_01121_y crossref_primary_10_1016_j_neurobiolaging_2024_12_012 crossref_primary_10_3389_fnins_2023_1099911 crossref_primary_10_1002_jmri_28874 crossref_primary_10_1002_mrm_30127 crossref_primary_10_3389_fnins_2023_1105816 crossref_primary_10_1002_nbm_5256 crossref_primary_10_1002_mrm_30415 crossref_primary_10_1016_j_bbi_2022_01_010 crossref_primary_10_1002_mrm_29581 crossref_primary_10_1002_mrm_29616 crossref_primary_10_1136_bmjopen_2023_081635 crossref_primary_10_1007_s00259_022_05997_1 crossref_primary_10_1177_0271678X241237733 crossref_primary_10_1002_jmri_28662 crossref_primary_10_1177_13872877251314138 crossref_primary_10_1002_alz_70104 crossref_primary_10_1002_mrm_70081 crossref_primary_10_3389_fradi_2025_1605777 crossref_primary_10_1007_s10334_024_01219_x crossref_primary_10_1002_mrm_70075 crossref_primary_10_3389_fnagi_2023_1132077 |
| Cites_doi | 10.1148/radiol.2016152244 10.1371/journal.pone.0104108 10.1002/mrm.28000 10.1109/TSP.2008.2005752 10.1038/jcbfm.2012.156 10.1002/mrm.1910230106 10.1038/sj.jcbfm.9600398 10.1002/mrm.27632 10.1002/mrm.10211 10.1002/mrm.20390 10.1002/mrm.21317 10.1002/1522-2594(200009)44:3<440::aid-mrm15<3.0.co;2-6 10.1002/mrm.23104 10.1016/j.neuron.2014.12.032 10.1073/pnas.89.1.212 10.1097/00004647-200104000-00013 10.1002/mrm.25197 10.1097/00004647-199611000-00019 10.1002/mrm.28496 10.1016/j.neuroimage.2018.12.026 10.1038/sj.jcbfm.9600337 10.1016/j.pnmrs.2019.09.002 10.1002/mrm.28687 10.1002/mrm.22165 10.1002/mrm.1136 10.1016/j.neuroimage.2015.08.025 10.3174/ajnr.A4586 10.1002/jmri.22345 10.1002/mrm.10158 10.1002/mrm.23019 10.1002/mrm.27141 10.1002/(sici)1099-1492(199706/08)10:4/5<237::aid-nbm475>3.0.co;2-x 10.1002/mrm.10180 10.1038/nrneurol.2017.188 10.1002/jmri.24493 10.1016/j.pscychresns.2008.04.003 10.1002/mrm.22601 10.1371/journal.pone.0171704 10.1002/jmri.23822 10.1038/jcbfm.2009.99 10.1016/j.neuroimage.2018.09.030 10.3389/fnins.2020.571480 10.1113/JP276887 10.1002/mrm.20580 |
| ContentType | Journal Article |
| Copyright | Copyright © 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther. Copyright © 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther. 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther |
| Copyright_xml | – notice: Copyright © 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther. – notice: Copyright © 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther. 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fnins.2021.719676 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1662-453X |
| ExternalDocumentID | oai_doaj_org_article_97e4c0ecad8847ab85ca08acc911c9b5 PMC8678075 34924924 10_3389_fnins_2021_719676 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: ; |
| GroupedDBID | --- 29H 2WC 53G 5GY 5VS 88I 8FE 8FH 9T4 AAFWJ AAYXX ABUWG ACGFO ACGFS ADRAZ AEGXH AENEX AFFHD AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AZQEC BBNVY BENPR BHPHI BPHCQ CCPQU CITATION CS3 DIK DU5 DWQXO E3Z EBS EJD EMOBN F5P FRP GNUQQ GROUPED_DOAJ GX1 HCIFZ HYE KQ8 LK8 M2P M48 M7P O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PQGLB PQQKQ PROAC RNS RPM W2D ACXDI C1A IAO IEA IHR ISR M~E NPM 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c465t-dfb7cd9209fcd2fba4aa14ccc2fd3aa116782b3971d94304ac2deacfbcffda903 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 26 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000731441100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1662-453X 1662-4548 |
| IngestDate | Fri Oct 03 12:51:02 EDT 2025 Tue Nov 04 02:01:54 EST 2025 Fri Sep 05 10:18:45 EDT 2025 Thu Jan 02 22:55:23 EST 2025 Sat Nov 29 02:55:10 EST 2025 Tue Nov 18 22:27:54 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | exchange time multi-TE ASL arterial spin labelling (ASL) MRI T2 relaxation blood–brain barrier (BBB) permeability |
| Language | English |
| License | Copyright © 2021 Mahroo, Buck, Huber, Breutigam, Mutsaerts, Craig, Chappell and Günther. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c465t-dfb7cd9209fcd2fba4aa14ccc2fd3aa116782b3971d94304ac2deacfbcffda903 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Laura Michelle Parkes, The University of Manchester, United Kingdom; Patricia Figueiredo, Universidade de Lisboa, Portugal This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience Edited by: Jens Wuerfel, University of Basel, Switzerland |
| OpenAccessLink | https://doaj.org/article/97e4c0ecad8847ab85ca08acc911c9b5 |
| PMID | 34924924 |
| PQID | 2612044857 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_97e4c0ecad8847ab85ca08acc911c9b5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8678075 proquest_miscellaneous_2612044857 pubmed_primary_34924924 crossref_citationtrail_10_3389_fnins_2021_719676 crossref_primary_10_3389_fnins_2021_719676 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-12-03 |
| PublicationDateYYYYMMDD | 2021-12-03 |
| PublicationDate_xml | – month: 12 year: 2021 text: 2021-12-03 day: 03 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in neuroscience |
| PublicationTitleAlternate | Front Neurosci |
| PublicationYear | 2021 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Varatharaj (B42) 2019; 597 Alsop (B1) 1996; 16 Buck (B6) 2021 Dickie (B11) 2019; 184 Schmid (B33) 2015; 123 Wong (B48) 1997; 10 Wells (B46) 2013; 33 Chen (B9) 2011; 33 Günther (B15) 2007 Dickie (B12) 2020; 116 Günther (B14) 2005; 54 Detre (B10) 1992; 23 Wells (B45) 2009; 29 Ohene (B28) 2021; 85 Wang (B44) 2007; 27 Atlas (B3) 2009 Mutsaerts (B26) 2014; 9 Chappell (B8) 2008; 57 Alsop (B2) 2015; 73 Olchowy (B31) 2017; 12 Ibaraki (B17) 2007; 27 Li (B20) 2005; 53 Shao (B34) 2019; 81 Barbier (B5) 2002; 47 Pinto (B30) 2020; 83 St Lawrence (B37) 2000; 44 He (B16) 2012; 67 Sousa (B36) 2014; 40 Williams (B47) 1992; 89 Wang (B43) 2002; 48 Ohene (B27) 2019; 188 Parkes (B29) 2002; 48 Kety (B19) 1951; 3 Shao (B35) 2020; 14 Zhou (B50) 2001; 21 St Lawrence (B38) 2012; 67 Sweeney (B40) 2018; 14 Liu (B23) 2011; 65 Raichle (B32) 1983; 24 Wu (B49) 2010; 63 Lin (B21) 2018; 80 van de Haar (B41) 2016; 281 Carr (B7) 2007; 58 Mahroo (B24) 2021 Montagne (B25) 2015; 85 Lin (B22) 2021; 86 Barbier (B4) 2001; 45 Kanda (B18) 2016; 37 Gregori (B13) 2013; 37 Starr (B39) 2009; 171 |
| References_xml | – volume: 281 start-page: 527 year: 2016 ident: B41 article-title: Blood-brain barrier leakage in patients with early Alzheimer disease. publication-title: Radiology doi: 10.1148/radiol.2016152244 – volume: 9 start-page: e104108 year: 2014 ident: B26 article-title: Inter-vendor reproducibility of pseudo-continuous arterial spin labeling at 3 Tesla. publication-title: PLoS One doi: 10.1371/journal.pone.0104108 – volume: 83 start-page: 1222 year: 2020 ident: B30 article-title: Calibration of arterial spin labeling data-potential pitfalls in post-processing. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.28000 – volume: 57 start-page: 223 year: 2008 ident: B8 article-title: Variational Bayesian inference for a nonlinear forward model. publication-title: IEEE Trans. Signal Process. doi: 10.1109/TSP.2008.2005752 – volume: 33 start-page: 215 year: 2013 ident: B46 article-title: Measuring biexponential transverse relaxation of the ASL signal at 9.4 T to estimate arterial oxygen saturation and the time of exchange of labeled blood water into cortical brain tissue. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2012.156 – volume: 23 start-page: 37 year: 1992 ident: B10 article-title: Perfusion imaging. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.1910230106 – volume: 27 start-page: 839 year: 2007 ident: B44 article-title: When perfusion meets diffusion: in vivo measurement of water permeability in human brain. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600398 – volume: 81 start-page: 3065 year: 2019 ident: B34 article-title: Mapping water exchange across the blood-brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.27632 – volume: 48 start-page: 242 year: 2002 ident: B43 article-title: Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.10211 – year: 2009 ident: B3 publication-title: Magnetic Resonance Imaging of the Brain and Spine. – volume: 53 start-page: 511 year: 2005 ident: B20 article-title: Four-phase single-capillary stepwise model for kinetics in arterial spin labeling MRI. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.20390 – volume: 3 start-page: 1 year: 1951 ident: B19 article-title: The theory and applications of the exchange of inert gas at the lungs and tissues. publication-title: Pharmacol. Rev. – volume: 58 start-page: 281 year: 2007 ident: B7 article-title: What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL? publication-title: Magn. Reson. Med. doi: 10.1002/mrm.21317 – year: 2007 ident: B15 article-title: Highly efficient accelerated acquisition of perfusion inflow series by cycled arterial spin labeling publication-title: Proceedings of the 15th Annual Meeting of ISMRM – volume: 44 start-page: 440 year: 2000 ident: B37 article-title: Effect of restricted water exchange on cerebral blood flow values calculated with arterial spin tagging: a theoretical investigation. publication-title: Magn. Reson. Med. doi: 10.1002/1522-2594(200009)44:3<440::aid-mrm15<3.0.co;2-6 – volume: 67 start-page: 1275 year: 2012 ident: B38 article-title: A two-stage approach for measuring vascular water exchange and arterial transit time by diffusion-weighted perfusion MRI. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.23104 – volume: 85 start-page: 296 year: 2015 ident: B25 article-title: Blood-brain barrier breakdown in the aging human hippocampus. publication-title: Neuron doi: 10.1016/j.neuron.2014.12.032 – volume: 89 start-page: 212 year: 1992 ident: B47 article-title: Magnetic resonance imaging of perfusion using spin inversion of arterial water. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.89.1.212 – volume: 21 start-page: 440 year: 2001 ident: B50 article-title: Two-compartment exchange model for perfusion quantification using arterial spin tagging. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/00004647-200104000-00013 – volume: 73 start-page: 102 year: 2015 ident: B2 article-title: Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.25197 – volume: 16 start-page: 1236 year: 1996 ident: B1 article-title: Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/00004647-199611000-00019 – volume: 85 start-page: 326 year: 2021 ident: B28 article-title: Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.28496 – volume: 188 start-page: 515 year: 2019 ident: B27 article-title: Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labeling: an aquaporin-4 study. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2018.12.026 – volume: 27 start-page: 404 year: 2007 ident: B17 article-title: Cerebral vascular mean transit time in healthy humans: a comparative study with PET and dynamic susceptibility contrast-enhanced MRI. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600337 – volume: 116 start-page: 19 year: 2020 ident: B12 article-title: Measuring water exchange across the blood-brain barrier using MRI. publication-title: Prog. Nucl Magn. Reson. Spectrosc. doi: 10.1016/j.pnmrs.2019.09.002 – year: 2021 ident: B6 article-title: “Considering intravoxel transit times is a must for robust determination of blood brain barrier integrity using arterial spin labeling,” publication-title: Proceedings of the 38th Annual Scientific Meeting of the ESMRMB [Online]. – volume: 86 start-page: 143 year: 2021 ident: B22 article-title: Noncontrast assessment of blood-brain barrier permeability to water: shorter acquisition, test-retest reproducibility, and comparison with contrast-based method. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.28687 – volume: 63 start-page: 601 year: 2010 ident: B49 article-title: Effects of CBV, CBF, and blood-brain barrier permeability on accuracy of PASL and VASO measurement. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.22165 – volume: 24 start-page: 790 year: 1983 ident: B32 article-title: Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. publication-title: J. Nucl. Med. – volume: 45 start-page: 1021 year: 2001 ident: B4 article-title: Perfusion imaging using dynamic arterial spin labeling (DASL). publication-title: Magn. Reson. Med. doi: 10.1002/mrm.1136 – volume: 123 start-page: 72 year: 2015 ident: B33 article-title: Time-efficient determination of spin compartments by time-encoded pCASL T2-relaxation-under-spin-tagging and its application in hemodynamic characterization of the cerebral border zones. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2015.08.025 – volume: 37 start-page: E1 year: 2016 ident: B18 article-title: Recent advances in understanding gadolinium retention in the brain. publication-title: AJNR Am. J. Neuroradiol. doi: 10.3174/ajnr.A4586 – volume: 33 start-page: 940 year: 2011 ident: B9 article-title: Test-retest reliability of arterial spin labeling with common labeling strategies. publication-title: J. Magn. Reson. Imaging doi: 10.1002/jmri.22345 – volume: 47 start-page: 1100 year: 2002 ident: B5 article-title: A model of blood-brain barrier permeability to water: accounting for blood inflow and longitudinal relaxation effects. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.10158 – volume: 67 start-page: 562 year: 2012 ident: B16 article-title: Transmembrane dynamics of water exchange in human brain. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.23019 – volume: 80 start-page: 1507 year: 2018 ident: B21 article-title: Non-contrast MR imaging of blood-brain barrier permeability to water. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.27141 – year: 2021 ident: B24 article-title: Robust blood brain barrier integrity measurements in a clinically significant short scan time publication-title: Poster Presented at the International Society for Magnetic Resonance in Medicine (ISMRM). – volume: 10 start-page: 237 year: 1997 ident: B48 article-title: Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. publication-title: NMR Biomed. doi: 10.1002/(sici)1099-1492(199706/08)10:4/5<237::aid-nbm475>3.0.co;2-x – volume: 48 start-page: 27 year: 2002 ident: B29 article-title: Improved accuracy of human cerebral blood perfusion measurements using arterial spin labeling: accounting for capillary water permeability. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.10180 – volume: 14 start-page: 133 year: 2018 ident: B40 article-title: Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. publication-title: Nat. Rev. Neurol. doi: 10.1038/nrneurol.2017.188 – volume: 40 start-page: 1453 year: 2014 ident: B36 article-title: Reproducibility of the quantification of arterial and tissue contributions in multiple postlabeling delay arterial spin labeling. publication-title: J. Magn. Reson. Imaging doi: 10.1002/jmri.24493 – volume: 171 start-page: 232 year: 2009 ident: B39 article-title: Blood-brain barrier permeability in Alzheimer’s disease: a case-control MRI study. publication-title: Psychiatry Res. doi: 10.1016/j.pscychresns.2008.04.003 – volume: 65 start-page: 120 year: 2011 ident: B23 article-title: Determination of spin compartment in arterial spin labeling MRI. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.22601 – volume: 12 start-page: e0171704 year: 2017 ident: B31 article-title: The presence of the gadolinium-based contrast agent depositions in the brain and symptoms of gadolinium neurotoxicity–a systematic review. publication-title: PLoS One doi: 10.1371/journal.pone.0171704 – volume: 37 start-page: 332 year: 2013 ident: B13 article-title: T2-based arterial spin labeling measurements of blood to tissue water transfer in human brain. publication-title: J. Magn. Reson. Imaging doi: 10.1002/jmri.23822 – volume: 29 start-page: 1836 year: 2009 ident: B45 article-title: Characterizing the origin of the arterial spin labeling signal in MRI using a multiecho acquisition approach. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2009.99 – volume: 184 start-page: 349 year: 2019 ident: B11 article-title: Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer’s disease rats. publication-title: Neuroimage doi: 10.1016/j.neuroimage.2018.09.030 – volume: 14 start-page: 571480 year: 2020 ident: B35 article-title: Comparison between blood-brain barrier water exchange rate and permeability to gadolinium-based contrast agent in an elderly cohort. publication-title: Front. Neurosci. doi: 10.3389/fnins.2020.571480 – volume: 597 start-page: 699 year: 2019 ident: B42 article-title: Blood-brain barrier permeability measured using dynamic contrast-enhanced magnetic resonance imaging: a validation study. publication-title: J. Physiol. doi: 10.1113/JP276887 – volume: 54 start-page: 491 year: 2005 ident: B14 article-title: Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements. publication-title: Magn. Reson. Med. doi: 10.1002/mrm.20580 |
| SSID | ssj0062842 |
| Score | 2.4182866 |
| Snippet | Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood–tissue exchange dynamics by probing the T2 relaxation of the labelled... Multiple echo-time arterial spin labelling (multi-TE ASL) offers estimation of blood-tissue exchange dynamics by probing the T2 relaxation of the labelled... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 719676 |
| SubjectTerms | arterial spin labelling (ASL) MRI blood–brain barrier (BBB) exchange time multi-TE ASL Neuroscience permeability T2 relaxation |
| Title | Robust Multi-TE ASL-Based Blood–Brain Barrier Integrity Measurements |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34924924 https://www.proquest.com/docview/2612044857 https://pubmed.ncbi.nlm.nih.gov/PMC8678075 https://doaj.org/article/97e4c0ecad8847ab85ca08acc911c9b5 |
| Volume | 15 |
| WOSCitedRecordID | wos000731441100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1662-453X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0062842 issn: 1662-453X databaseCode: DOA dateStart: 20070101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1662-453X dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062842 issn: 1662-453X databaseCode: M7P dateStart: 20071015 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1662-453X dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062842 issn: 1662-453X databaseCode: BENPR dateStart: 20071015 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1662-453X dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062842 issn: 1662-453X databaseCode: PIMPY dateStart: 20071015 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1662-453X dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062842 issn: 1662-453X databaseCode: M2P dateStart: 20071015 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NjtMwEB7BLgcuCFh-ukBlJMQBKWzipnF8bFArVtpW0bJI5RTZ41hUghT1ZyVuvANvyJMw47SlRQguSJFlJY7szIw9M_bkG4AXcd9aEoUsUnlNDopOk0hLqhmfKaeMTQ0GnNkLNZnk06ku91J9cUxYCw_cEu5MqzrFuEbjclpIjc37aOLcINIsRW0DeilZPVtnql2DM1p0ZXuGSS6YPvPNrGFsbpm8ViRyDDCyp4UCWP-fLMzfAyX3NM_oLtzZmIxi0A71Htyom_twMmjIXf78VbwUIYgz7I6fwOhybtfLlQj_1UZXQzF4dxEVpKmcKDhE_ce37wUnhRCFWXCuOnEe4CLIFBfjX7uFywfwfjS8evM22qRKiDDN-qvIeavQaRlrj056a1JjkhQRpXc9qiakk6Ql2yNxjLdOHJCOllxv0XtndNx7CEfNvKkfgzB1rLLUZ7rPqUgwsVZlKKUjO0vJ3KsOxFvSVbjBEed0Fp8q8ieY2lWgdsXUrlpqd-DV7pUvLYjG3xoXzI9dQ8a_DjdIKqqNVFT_kooOPN9ys6L5wocgpqnna-qJTLqYfNI-fcijlru7rhipka8OqAO-H4zl8Ekz-xgwuXMiMFlfp_9j8E_gNtMjBM30nsLRarGun8EtvF7Nlosu3FTTvAvHxXBSXnaD2FM5liWXisrj8nxcfvgJZXwNmw |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Robust+Multi-TE+ASL-Based+Blood%E2%80%93Brain+Barrier+Integrity+Measurements&rft.jtitle=Frontiers+in+neuroscience&rft.au=Amnah+Mahroo&rft.au=Mareike+Alicja+Buck&rft.au=Mareike+Alicja+Buck&rft.au=J%C3%B6rn+Huber&rft.date=2021-12-03&rft.pub=Frontiers+Media+S.A&rft.eissn=1662-453X&rft.volume=15&rft_id=info:doi/10.3389%2Ffnins.2021.719676&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_97e4c0ecad8847ab85ca08acc911c9b5 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-453X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-453X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-453X&client=summon |