HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

Histone deacetylases (HDACs) are a group of enzymes that control histone deacetylation and bear potential to direct expression of large gene sets. We determined the effect of HDAC inhibitors (HDACi) on human monocytes and macrophages, with respect to their polarization, activation, and their capabil...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 11; p. 550769
Main Authors:	Ghiboub, Mohammed, Zhao, Jing, Li Yim, Andrew Y. F., Schilderink, Ronald, Verseijden, Caroline, van Hamersveld, Patricia H. P., Duarte, Jose M., Hakvoort, Theodorus B. M., Admiraal, Iris, Harker, Nicola R., Tough, David F., Henneman, Peter, de Winther, Menno P. J., de Jonge, Wouter J.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 05.10.2020
Subjects:	Cytokines - genetics Cytokines - metabolism Enzyme Activation Gene Expression HDAC3 inhibition Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans IFNγ Immune Tolerance - drug effects Immunology Immunophenotyping Inflammation - drug therapy Inflammation - etiology Inflammation - metabolism Inflammation - pathology inflammatory response Lipopolysaccharides - immunology LPS tolerance Macrophage Activation - drug effects Macrophage Activation - immunology macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Protein Binding IFNγ HDAC3 inhibition inflammatory response macrophages LPS tolerance
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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