Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscilla...

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Veröffentlicht in:	Cell Jg. 142; H. 6; S. 943
Hauptverfasser:	Asher, Gad, Reinke, Hans, Altmeyer, Matthias, Gutierrez-Arcelus, Maria, Hottiger, Michael O, Schibler, Ueli
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.09.2010
Schlagworte:	Animals Biological Clocks Circadian Rhythm Circadian Rhythm Signaling Peptides and Proteins - metabolism Feeding Behavior Liver - metabolism Mice Mice, Knockout Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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