Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in liver the activity of PARP-1, an NAD(+)-dependent ADP-ribosyltransferase, oscilla...

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Vydané v:	Cell Ročník 142; číslo 6; s. 943
Hlavní autori:	Asher, Gad, Reinke, Hans, Altmeyer, Matthias, Gutierrez-Arcelus, Maria, Hottiger, Michael O, Schibler, Ueli
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 17.09.2010
Predmet:	Animals Biological Clocks Circadian Rhythm Circadian Rhythm Signaling Peptides and Proteins - metabolism Feeding Behavior Liver - metabolism Mice Mice, Knockout Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism
ISSN:	1097-4172, 1097-4172
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