Plasma Metabolome Profiling for the Diagnosis of Catecholamine Producing Tumors

Pheochromocytomas and paragangliomas (PPGL) cause catecholamine excess leading to a characteristic clinical phenotype. Intra-individual changes at metabolome level have been described after surgical PPGL removal. The value of metabolomics for the diagnosis of PPGL has not been studied yet. Evaluatio...

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Bibliographic Details
Published in:	Frontiers in endocrinology (Lausanne) Vol. 12; p. 722656
Main Authors:	März, Juliane, Kurlbaum, Max, Roche-Lancaster, Oisin, Deutschbein, Timo, Peitzsch, Mirko, Prehn, Cornelia, Weismann, Dirk, Robledo, Mercedes, Adamski, Jerzy, Fassnacht, Martin, Kunz, Meik, Kroiss, Matthias
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 07.09.2021
Subjects:	adrenal Adrenal Gland Neoplasms - blood Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - metabolism Adult Blood Cells - metabolism Blood Chemical Analysis - methods Case-Control Studies catecholamines Catecholamines - metabolism Chromatography, Liquid Endocrinology Female Germany Humans Male mass spectronomy Metabolome Metabolomics - methods Middle Aged paraganglioma Paraganglioma - blood Paraganglioma - diagnosis Paraganglioma - metabolism pheochromocytoma Pheochromocytoma - blood Pheochromocytoma - diagnosis Pheochromocytoma - metabolism Tandem Mass Spectrometry targeted metabolomics Germany catecholamines adrenal pheochromocytoma targeted metabolomics mass spectronomy machine learning feature selection paraganglioma
ISSN:	1664-2392, 1664-2392
Online Access:	Get full text
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