Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics

Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding "invagination" and "metaplasia" theories. The endometrial-myometrial junction (EMJ) connects the endometrium and myometrium and is important for diagnosing and c...

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Vydáno v:	Protein & cell Ročník 15; číslo 7; s. 530 - 546
Hlavní autoři:	Chen, Tao, Xu, Yiliang, Xu, Xiaocui, Wang, Jianzhang, Qiu, Zhiruo, Yu, Yayuan, Jiang, Xiaohong, Shao, Wanqi, Bai, Dandan, Wang, Mingzhu, Mei, Shuyan, Cheng, Tao, Wu, Li, Gao, Shaorong, Che, Xuan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Germany Higher Education Press 01.07.2024 Springer Nature B.V Oxford University Press
Témata:	adenomyosis Adenomyosis - genetics Adenomyosis - metabolism Adenomyosis - pathology Angiogenesis Angiopoietin Cell interactions endometrial-myometrial junction Endometrium Endometrium - metabolism Endometrium - pathology Endothelial cells Female Humans Lesions Metaplasia Myometrium Myometrium - metabolism Myometrium - pathology Pleiotrophin Progenitor cells Sequence Analysis, RNA Single-Cell Analysis single-cell RNA sequencing spatial transcriptomics Transcriptome Transcriptomics Vascular endothelial growth factor Wnt protein single-cell RNA sequencing progenitor cells endometrial-myometrial junction spatial transcriptomics adenomyosis
ISSN:	1674-800X, 1674-8018, 1674-8018
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