Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis

COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory response that can lead to severe complications and multi-organ damage. Mortality in COVID-19 patients is associated with...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 13; p. 880961
Main Authors:	Aloul, Karim M., Nielsen, Josefine Eilsø, Defensor, Erwin B., Lin, Jennifer S., Fortkort, John A., Shamloo, Mehrdad, Cirillo, Jeffrey D., Gombart, Adrian F., Barron, Annelise E.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 12.05.2022
Subjects:	alpha synuclein Animals Antimicrobial Cationic Peptides Antimicrobial Peptides Cathelicidins COVID-19 diabetes Humans Immunology LL-37 NET clearance Peptidyl-Dipeptidase A - metabolism SARS-CoV-2 COVID-19 NET clearance SARS-CoV-2 LL-37 neutrophil extracellular trap (NET) cathelicidin alpha synuclein diabetes
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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