Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals

Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT R) binding. However, the associatio...

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Veröffentlicht in:Frontiers in psychology Jg. 13; S. 948729
Hauptverfasser: Søndergaard, Anna, Madsen, Martin Korsbak, Ozenne, Brice, Armand, Sophia, Knudsen, Gitte Moos, Fisher, Patrick MacDonald, Stenbæk, Dea Siggaard
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Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 05.10.2022
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ISSN:1664-1078, 1664-1078
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Abstract Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT R) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT R binding in the healthy brain. We evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT R binding in neocortex and selected frontolimbic regions. Forty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [ C]-Cimbi-36 positron emission tomography (PET) to assess 5-HT R binding in neocortex and, , in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex. The MAAS score was significantly increased at 3-month follow-up ( = 3.24 × 10 ), a change positively associated with the MEQ score ( = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT R binding was not significant ( = 0.24), analyses revealed a significant negative association between MAAS and right amygdala 5-HT R binding (p = 0.008). We here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT R binding in the right amygdala.
AbstractList Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT R) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT R binding in the healthy brain. We evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT R binding in neocortex and selected frontolimbic regions. Forty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [ C]-Cimbi-36 positron emission tomography (PET) to assess 5-HT R binding in neocortex and, , in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex. The MAAS score was significantly increased at 3-month follow-up ( = 3.24 × 10 ), a change positively associated with the MEQ score ( = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT R binding was not significant ( = 0.24), analyses revealed a significant negative association between MAAS and right amygdala 5-HT R binding (p = 0.008). We here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT R binding in the right amygdala.
Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT2AR) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT2AR binding in the healthy brain.BackgroundPsilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT2AR) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT2AR binding in the healthy brain.We evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT2AR binding in neocortex and selected frontolimbic regions.AimWe evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT2AR binding in neocortex and selected frontolimbic regions.Forty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [11C]-Cimbi-36 positron emission tomography (PET) to assess 5-HT2AR binding in neocortex and, post-hoc, in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex.Materials and methodsForty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [11C]-Cimbi-36 positron emission tomography (PET) to assess 5-HT2AR binding in neocortex and, post-hoc, in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex.The MAAS score was significantly increased at 3-month follow-up (p = 3.24 × 10-6), a change positively associated with the MEQ score (p = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT2AR binding was not significant (p = 0.24), post-hoc analyses revealed a significant negative association between MAAS and right amygdala 5-HT2AR binding (pFWER = 0.008).ResultsThe MAAS score was significantly increased at 3-month follow-up (p = 3.24 × 10-6), a change positively associated with the MEQ score (p = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT2AR binding was not significant (p = 0.24), post-hoc analyses revealed a significant negative association between MAAS and right amygdala 5-HT2AR binding (pFWER = 0.008).We here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT2AR binding in the right amygdala.ConclusionWe here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT2AR binding in the right amygdala.
BackgroundPsilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT2AR) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT2AR binding in the healthy brain.AimWe evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-drug trait mindfulness and 5-HT2AR binding in neocortex and selected frontolimbic regions.Materials and methodsForty-six medium-high dose psilocybin sessions were conducted in 39 healthy individuals. The mystical-type experience was measured with the Mystical Experience Questionnaire (MEQ) at the end of the session. Trait mindfulness was measured using the Mindful Attention and Awareness Scale (MAAS) at baseline and 3 months after the psilocybin session. Thirty-two of the participants completed pre-drug [11C]-Cimbi-36 positron emission tomography (PET) to assess 5-HT2AR binding in neocortex and, post-hoc, in the frontolimbic regions amygdala, frontal cortex, and anterior cingulate cortex.ResultsThe MAAS score was significantly increased at 3-month follow-up (p = 3.24 × 10–6), a change positively associated with the MEQ score (p = 0.035). Although the association between pre-drug MAAS score and neocortex 5-HT2AR binding was not significant (p = 0.24), post-hoc analyses revealed a significant negative association between MAAS and right amygdala 5-HT2AR binding (pFWER = 0.008).ConclusionWe here show that lasting changes in trait mindfulness following psilocybin administration are positively associated with intensity of the mystical-type experience, suggesting that the acute phenomenology of psilocybin facilitates a shift in awareness conducive for mindful living. We furthermore show that higher pre-drug trait mindfulness is associated with reduced 5-HT2AR binding in the right amygdala.
Author Fisher, Patrick MacDonald
Armand, Sophia
Ozenne, Brice
Madsen, Martin Korsbak
Stenbæk, Dea Siggaard
Søndergaard, Anna
Knudsen, Gitte Moos
AuthorAffiliation 2 Institute of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark
4 Section of Biostatistics, Department of Public Health, University of Copenhagen , Copenhagen , Denmark
5 Institute of Psychology, University of Copenhagen , Copenhagen , Denmark
1 Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark
3 Department of Psychiatry, University Hospital Svendborg , Svendborg , Denmark
AuthorAffiliation_xml – name: 2 Institute of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark
– name: 4 Section of Biostatistics, Department of Public Health, University of Copenhagen , Copenhagen , Denmark
– name: 3 Department of Psychiatry, University Hospital Svendborg , Svendborg , Denmark
– name: 5 Institute of Psychology, University of Copenhagen , Copenhagen , Denmark
– name: 1 Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark
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Keywords psychedelics
serotonin 2A receptor
[11C]-Cimbi-36
mindfulness
mystical experience
psilocybin
Mindful Attention and Awareness Scale
Language English
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Snippet Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is...
BackgroundPsilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait...
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SubjectTerms [11C]-Cimbi-36
mindfulness
mystical experience
psilocybin
psychedelics
Psychology
serotonin 2A receptor
Title Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals
URI https://www.ncbi.nlm.nih.gov/pubmed/36275302
https://www.proquest.com/docview/2728146362
https://pubmed.ncbi.nlm.nih.gov/PMC9580465
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