Novel association of CHEK2 mutation in gastrointestinal stromal tumor: A case report and literature review

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, typically driven by mutations inc-KITorPDGFRA. TheCHEK2gene encodes a checkpoint kinase involved in DNA damage response and has been implicated in hereditary cancer syndromes. However, its r...

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Veröffentlicht in:	Human Pathology Reports Jg. 42; S. 300794
Hauptverfasser:	Hu, Trevor T, Pazhyattil, Joyce, Richman, Allison M., Henderson, Kathryn, Groh, Darren, Abdulrahim, Ahmed F.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier Inc 01.11.2025 Elsevier
Schlagworte:	c-KIT CHEK2 mutation DNA damage response Gastrointestinal stromal tumor Pathology Tyrosine kinase inhibitors CHEK2 mutation c-KIT DNA damage response Tyrosine kinase inhibitors Gastrointestinal stromal tumor
ISSN:	2772-736X, 2772-736X
Online-Zugang:	Volltext
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