Challenges to Improve Bone Healing Under Diabetic Conditions

Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc. Improving bone healing in diabetic patients has important clinica...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) Vol. 13; p. 861878
Main Authors: Chen, Yiling, Zhou, Yue, Lin, Jie, Zhang, Shiwen
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 28.03.2022
Subjects:
biomedical cues
bone healing
Diabetes Mellitus - therapy
diabetic bone disease
diabetic drug
Endocrinology
Fracture Healing
Glycation End Products, Advanced - metabolism
Humans
hyperglycemia
mesenchymal stem cells
Oxidative Stress
hyperglycemia
diabetic bone disease
diabetic drug
biomedical cues
mesenchymal stem cells
bone healing
ISSN:1664-2392, 1664-2392
Online Access:Get full text
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Summary:Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc. Improving bone healing in diabetic patients has important clinical significance in promoting fracture healing and improving bone integration. In this paper, we reviewed the methods of improving bone healing under diabetic conditions, including drug therapy, biochemical cues, hyperbaric oxygen, ultrasound, laser and pulsed electromagnetic fields, although most studies are in preclinical stages. Meanwhile, we also pointed out some shortcomings and challenges, hoping to provide a potential therapeutic strategy for accelerating bone healing in patients with diabetes.
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content type line 23
Reviewed by: Akalpita Arvindekar, Shivaji University, India; Ernesto Maddaloni, Sapienza University of Rome, Italy
This article was submitted to Bone Research, a section of the journal Frontiers in Endocrinology
These authors have contributed equally to this work and share first authorship
Edited by: Melissa Orlandin Premaor, Federal University of Minas Gerais, Brazil
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.861878