EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor–stroma interaction

Elevated levels of EMMPRIN/CD147 in cancer tissues have been correlated with tumor progression but the regulation of its expression is not yet understood. Here, the regulation of EMMPRIN expression was investigated in testicular germ cell tumor (TGCTs) cell lines. EMMPRIN expression in seminoma JKT-...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1840; H. 8; S. 2581 - 2588
Hauptverfasser:	Milia-Argeiti, Eleni, Mourah, Samia, Vallée, Benoit, Huet, Eric, Karamanos, Nikos K., Theocharis, Achilleas D., Menashi, Suzanne
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.08.2014
Schlagworte:	Basigin - genetics Basigin - metabolism carcinoma Cell Communication Cell Line, Tumor Cell Membrane - metabolism cell membranes Embryonic carcinoma EMMPRIN/CD147 fibroblasts Fibroblasts - enzymology Fibroblasts - pathology fluorescent antibody technique Gene Expression Regulation, Neoplastic germ cells Humans Male Matrix Metalloproteinase 2 - biosynthesis Membrane Microdomains - metabolism Membrane vesicles (MVs) messenger RNA MMPs neoplasm cells Neoplasms, Germ Cell and Embryonal - enzymology Neoplasms, Germ Cell and Embryonal - genetics Neoplasms, Germ Cell and Embryonal - pathology Phenotype protein degradation quantitative polymerase chain reaction reverse transcriptase polymerase chain reaction RNA, Messenger - genetics RNA, Messenger - metabolism secretion Secretory Vesicles - metabolism Seminoma small interfering RNA Stromal Cells - pathology testes Testicular germ cell Testicular Neoplasms - enzymology Testicular Neoplasms - genetics Testicular Neoplasms - pathology Western blotting Seminoma Embryonic carcinoma Membrane vesicles (MVs) EMMPRIN/CD147 MMPs Testicular germ cell
ISSN:	0304-4165, 0006-3002, 1872-8006
Online-Zugang:	Volltext
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