Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. A better understanding of this disease would greatly benefit from the availability of representative preclinical models. Here, we present the potential of tumor organoids, three-d...

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Bibliographic Details
Published in:	Frontiers in endocrinology (Lausanne) Vol. 12; p. 627819
Main Authors:	Dijkstra, Krijn K., van den Berg, José G., Weeber, Fleur, van de Haar, Joris, Velds, Arno, Kaing, Sovann, Peters, Dennis D. G. C., Eskens, Ferry A. L. M., de Groot, Derk-Jan A., Tesselaar, Margot E. T., Voest, Emile E.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 11.03.2021
Subjects:	Cell Death - drug effects Cell Line, Tumor Cisplatin - pharmacology Cisplatin - therapeutic use disease modeling DNA Mismatch Repair - drug effects Endocrinology Everolimus - pharmacology Everolimus - therapeutic use extrapulmonary neuroendocrine carcinoma gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) Gene Dosage Humans Intestinal Neoplasms - drug therapy Intestinal Neoplasms - genetics Intestinal Neoplasms - pathology Ki-67 Antigen - metabolism Models, Biological Mutation - genetics Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - genetics Neuroendocrine Tumors - pathology organoids Organoids - drug effects Organoids - metabolism Organoids - pathology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology pre-clinical models Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Whole Exome Sequencing organoids pre-clinical models disease modeling gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) extrapulmonary neuroendocrine carcinoma
ISSN:	1664-2392, 1664-2392
Online Access:	Get full text
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