Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The ex...

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Vydané v:	Oncotarget Ročník 8; číslo 40; s. 67269
Hlavní autori:	De Francesco, Ernestina Marianna, Bonuccelli, Gloria, Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.09.2017
Predmet:	cancer stem-like cells (CSCs) doxycycline vitamin C mitochondrial biogenesis mitochondrial DNA (mt-DNA)
ISSN:	1949-2553, 1949-2553
On-line prístup:	Zistit podrobnosti o prístupe
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