Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The ex...

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Bibliographic Details

Published in:	Oncotarget Vol. 8; no. 40; p. 67269
Main Authors:	De Francesco, Ernestina Marianna, Bonuccelli, Gloria, Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States 15.09.2017
Subjects:	cancer stem-like cells (CSCs) doxycycline vitamin C mitochondrial biogenesis mitochondrial DNA (mt-DNA)
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
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