New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be r...
Uloženo v:
| Vydáno v: | Frontiers in endocrinology (Lausanne) Ročník 11; s. 606434 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Switzerland
Frontiers Media S.A
05.01.2021
|
| Témata: | |
| ISSN: | 1664-2392, 1664-2392 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their “attraction” to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis. |
|---|---|
| AbstractList | Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their “attraction” to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis. Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing "dogmas", mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their "attraction" to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis.Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing "dogmas", mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their "attraction" to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis. |
| Author | Bender, Christine Rajendran, Sakthi von Herrath, Matthias G. |
| AuthorAffiliation | Center for Autoimmunity and Inflammation, Type 1 Diabetes Center at La Jolla Institute for Immunology , La Jolla, CA , United States |
| AuthorAffiliation_xml | – name: Center for Autoimmunity and Inflammation, Type 1 Diabetes Center at La Jolla Institute for Immunology , La Jolla, CA , United States |
| Author_xml | – sequence: 1 givenname: Christine surname: Bender fullname: Bender, Christine – sequence: 2 givenname: Sakthi surname: Rajendran fullname: Rajendran, Sakthi – sequence: 3 givenname: Matthias G. surname: von Herrath fullname: von Herrath, Matthias G. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33469446$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kkFvGyEQhVGVqknT_IBeKo692GUAs8ulUrRJG0tRKlXusUKzLGuTrsFdcCr_--I4iZJK5cLTMO8bBO8tOQoxOELeA5sKUetPvQtdnHLG2VQxJYV8RU5AKTnhQvOjZ_qYnKV0y8qSDLSu35BjIaTSUqoT8vPG_aHzkPxylVMROdK8cvR7HByNPT3f5jg6tNnfOdpc1HRBGzcMiWLoaLPL8ZcPLlEf6NV2jYEudhtHgV54bF126R153eOQ3NnDfkp-fLlcNFeT629f58359cRKNcuTCpVGAMByw5kAFDCD1jpZV1JaaGVXM-zautetUDUo5LzHokHquhKCM3FK5gduF_HWbEa_xnFnInpzX4jj0uCYvR2cYS22PTJrldRSA9dKAOeCQ8srZCAL6_OBtdm2a9dZF_KIwwvoy5PgV2YZ70xVg9CaF8DHB8AYf29dymbtky2vhsHFbTJcVlqCVrourR-ez3oa8vg_paE6NNgxpjS63lifMfu4H-0HA8zsw2Duw2D2YTCHMBQn_ON8hP_f8xe2tbVa |
| CitedBy_id | crossref_primary_10_1097_CD9_0000000000000096 crossref_primary_10_3389_fendo_2024_1377322 crossref_primary_10_3390_antib13020027 crossref_primary_10_1002_psb_2016 crossref_primary_10_3389_fimmu_2025_1506500 crossref_primary_10_1038_s41590_021_01073_2 crossref_primary_10_1210_endocr_bqad162 crossref_primary_10_1016_j_mito_2023_07_002 crossref_primary_10_3389_fimmu_2023_1292238 crossref_primary_10_1016_j_molmet_2021_101417 crossref_primary_10_1007_s00125_021_05565_6 crossref_primary_10_1007_s00125_024_06106_7 crossref_primary_10_3389_fimmu_2023_1326711 crossref_primary_10_1007_s40265_025_02150_8 crossref_primary_10_1159_000542002 crossref_primary_10_3390_vaccines13040405 crossref_primary_10_1016_j_phrs_2024_107433 crossref_primary_10_1007_s11882_025_01211_y crossref_primary_10_1038_s41401_023_01207_2 crossref_primary_10_7759_cureus_57894 crossref_primary_10_1371_journal_pone_0298457 crossref_primary_10_1073_pnas_2219956120 crossref_primary_10_1093_cei_uxad083 crossref_primary_10_1155_2021_3511281 crossref_primary_10_1038_s41598_024_73737_6 crossref_primary_10_1159_000524866 crossref_primary_10_1007_s00125_023_05970_z crossref_primary_10_1007_s12015_023_10668_1 crossref_primary_10_3390_vaccines12030276 crossref_primary_10_1080_1744666X_2022_2045952 crossref_primary_10_1016_j_fbio_2025_107539 crossref_primary_10_1210_jendso_bvad160 crossref_primary_10_3390_jcm14020418 crossref_primary_10_1212_NXI_0000000000200117 |
| Cites_doi | 10.2337/db19-0239 10.1371/journal.pgen.1002552 10.1172/JCI94549 10.1042/BSR20090021 10.4049/jimmunol.168.3.1001 10.2337/db14-0549 10.1084/jem.20111187 10.1016/j.immuni.2015.05.001 10.2337/db15-0779 10.1038/nm1202-792 10.2337/db17-0666 10.4161/19382014.2014.950547 10.1111/j.1600-065X.2011.01014.x 10.2337/db11-1520 10.1111/j.1365-2249.2008.03860.x 10.1111/j.1365-2249.2009.04087.x 10.2337/db14-0858 10.3389/fendo.2017.00343 10.1111/cei.13391 10.2337/db16-1343 10.1038/ng0397-293 10.2337/db14-1020 10.1038/nm.4203 10.1172/JCI6438 10.1172/JCI126595 10.1007/s00125-015-3669-6 10.1016/j.jaut.2017.03.006 10.1016/j.clim.2020.108394 10.1016/j.celrep.2019.11.056 10.1126/sciimmunol.aao4013 10.1038/nri3084 10.1016/j.cmet.2018.07.007 10.1016/j.clim.2019.108320 10.2337/diabetes.50.12.2744 10.2337/diabetes.51.5.1383 10.2337/db16-1025 10.2337/db11-1547 10.3389/fendo.2020.00630 10.1016/j.ebiom.2018.09.040 10.3389/fimmu.2017.02001 10.2337/db09-1486 10.1073/pnas.0801059105 10.1507/endocrj.K10E-076 10.4049/jimmunol.174.5.2746 10.2337/db14-0332 10.2337/db16-0616 10.1126/sciadv.abc5586 10.1007/s00125-016-4201-3 10.1084/jem.20021378 10.1007/s00125-016-4067-4 10.1007/s00125-012-2604-3 10.1530/eje.1.01856 |
| ContentType | Journal Article |
| Copyright | Copyright © 2021 Bender, Rajendran and von Herrath. Copyright © 2021 Bender, Rajendran and von Herrath 2021 Bender, Rajendran and von Herrath |
| Copyright_xml | – notice: Copyright © 2021 Bender, Rajendran and von Herrath. – notice: Copyright © 2021 Bender, Rajendran and von Herrath 2021 Bender, Rajendran and von Herrath |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fendo.2020.606434 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1664-2392 |
| ExternalDocumentID | oai_doaj_org_article_0babfa0cc6494912963122321b27a014 PMC7813992 33469446 10_3389_fendo_2020_606434 |
| Genre | Journal Article Review Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: R01 AI134971 – fundername: NIAID NIH HHS grantid: R01 AI092453 – fundername: National Institutes of Health |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RPM ACXDI IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c465t-7a69a111a040531a3151bce48744c1b4d80adb8f9b36816a22fa9b31498733203 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 43 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000608463200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1664-2392 |
| IngestDate | Fri Oct 03 12:45:42 EDT 2025 Thu Aug 21 13:49:45 EDT 2025 Fri Sep 05 11:24:42 EDT 2025 Thu Jan 02 22:57:30 EST 2025 Sat Nov 29 06:38:04 EST 2025 Tue Nov 18 21:07:27 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | type 1 diabetes cytokines autoreactive CD8 T cells beta cells human pancreas |
| Language | English |
| License | Copyright © 2021 Bender, Rajendran and von Herrath. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c465t-7a69a111a040531a3151bce48744c1b4d80adb8f9b36816a22fa9b31498733203 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Todd M. Brusko, University of Florida, United States Reviewed by: Guido Sebastiani, University of Siena, Italy; Eddie A. James, Benaroya Research Institute, United States; Francesco Dotta, University of Siena, Italy; Stuart Ian Mannering, University of Melbourne, Australia Present Address: Sakthi Rajendran, Nationwide Children’s Hospital, Columbus, United States These authors have contributed equally to this work This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology |
| OpenAccessLink | https://doaj.org/article/0babfa0cc6494912963122321b27a014 |
| PMID | 33469446 |
| PQID | 2479419698 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_0babfa0cc6494912963122321b27a014 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7813992 proquest_miscellaneous_2479419698 pubmed_primary_33469446 crossref_citationtrail_10_3389_fendo_2020_606434 crossref_primary_10_3389_fendo_2020_606434 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-01-05 |
| PublicationDateYYYYMMDD | 2021-01-05 |
| PublicationDate_xml | – month: 01 year: 2021 text: 2021-01-05 day: 05 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in endocrinology (Lausanne) |
| PublicationTitleAlternate | Front Endocrinol (Lausanne) |
| PublicationYear | 2021 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Kronenberg (B7) 2012; 61 Santangelo (B48) 2005; 152 Rajendran (B27) 2020; 214 Culina (B4) 2018; 3 Espinosa-Carrasco (B13) 2017; 8 Skowera (B6) 2015; 64 Kaminski (B29) 2009; 30 Chentoufi (B16) 2002; 51 Babon (B8) 2016; 22 Ellingsgaard (B26) 2008; 105 Lundberg (B43) 2016; 65 Eizirik (B44) 2012; 8 Chong (B47) 2001; 50 Gallagher (B34) 2015; 64 Colli (B46) 2018; 36 Weisberg (B20) 2019; 29 Michels (B22) 2017; 66 Burrack (B14) 2017; 8 Anquetil (B25) 2017; 81 Gonzalez-Duque (B9) 2018; 28 Pugliese (B2) 2017; 127 Hostens (B45) 1999; 104 Chen (B41) 2002; 168 Campbell-Thompson (B1) 2016; 65 Dissanayake (B51) 2011; 241 Coppieters (B21) 2012; 209 Spanier (B23) 2017; 66 Rodriguez-Calvo (B18) 2014; 63 Rajendran (B24) 2020; 211 Uno (B37) 2010; 57 Yu (B5) 2015; 42 Nigi (B38) 2020; 11 Wiedeman (B52) 2020; 130 Velthuis (B3) 2010; 59 Marroqui (B32) 2017; 60 Roep (B36) 2010; 159 Bender (B15) 2020; 6 Gonzalez Badillo (B42) 2019; 68 Savinov (B31) 2003; 197 Neefjes (B11) 2011; 11 Yeo (B10) 2020; 199 Rodriguez-Calvo (B35) 2017; 66 Pugliese (B17) 1997; 15 Schulte (B33) 2012; 61 Brozzi (B50) 2015; 58 Pathiraja (B12) 2015; 64 Richardson (B30) 2016; 59 Russell (B28) 2014; 6 Marhfour (B49) 2012; 55 Willcox (B19) 2009; 155 Ejrnaes (B40) 2005; 174 Frigerio (B39) 2002; 8 |
| References_xml | – volume: 68 start-page: 1990 year: 2019 ident: B42 article-title: CCL21 Expression in beta-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice publication-title: Diabetes doi: 10.2337/db19-0239 – volume: 8 start-page: e1002552 year: 2012 ident: B44 article-title: The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines publication-title: PloS Genet doi: 10.1371/journal.pgen.1002552 – volume: 127 year: 2017 ident: B2 article-title: Autoreactive T cells in type 1 diabetes publication-title: J Clin Invest doi: 10.1172/JCI94549 – volume: 30 year: 2009 ident: B29 article-title: Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways publication-title: Biosci Rep doi: 10.1042/BSR20090021 – volume: 168 year: 2002 ident: B41 article-title: Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice publication-title: J Immunol doi: 10.4049/jimmunol.168.3.1001 – volume: 63 year: 2014 ident: B18 article-title: Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes publication-title: Diabetes doi: 10.2337/db14-0549 – volume: 209 start-page: 51 year: 2012 ident: B21 article-title: Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients publication-title: J Exp Med doi: 10.1084/jem.20111187 – volume: 42 year: 2015 ident: B5 article-title: Clonal Deletion Prunes but Does Not Eliminate Self-Specific alphabeta CD8(+) T Lymphocytes publication-title: Immunity doi: 10.1016/j.immuni.2015.05.001 – volume: 65 year: 2016 ident: B1 article-title: Insulitis and beta-Cell Mass in the Natural History of Type 1 Diabetes publication-title: Diabetes doi: 10.2337/db15-0779 – volume: 8 year: 2002 ident: B39 article-title: Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis publication-title: Nat Med doi: 10.1038/nm1202-792 – volume: 66 year: 2017 ident: B23 article-title: Increased Effector Memory Insulin-Specific CD4(+) T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes publication-title: Diabetes doi: 10.2337/db17-0666 – volume: 6 start-page: e950547 year: 2014 ident: B28 article-title: The impact of anti-inflammatory cytokines on the pancreatic beta-cell publication-title: Islets doi: 10.4161/19382014.2014.950547 – volume: 241 year: 2011 ident: B51 article-title: Immunological perspective of self versus tumor antigens: insights from the RIP-gp model publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2011.01014.x – volume: 61 year: 2012 ident: B7 article-title: Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill beta-cells publication-title: Diabetes doi: 10.2337/db11-1520 – volume: 155 year: 2009 ident: B19 article-title: Analysis of islet inflammation in human type 1 diabetes publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2008.03860.x – volume: 159 year: 2010 ident: B36 article-title: Islet inflammation and CXCL10 in recent-onset type 1 diabetes publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2009.04087.x – volume: 64 year: 2015 ident: B12 article-title: Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes publication-title: Diabetes doi: 10.2337/db14-0858 – volume: 8 year: 2017 ident: B14 article-title: T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2017.00343 – volume: 199 year: 2020 ident: B10 article-title: Circulating beta cell-specific CD8(+) T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes publication-title: Clin Exp Immunol doi: 10.1111/cei.13391 – volume: 66 year: 2017 ident: B35 article-title: Increase in Pancreatic Proinsulin and Preservation of beta-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset publication-title: Diabetes doi: 10.2337/db16-1343 – volume: 15 year: 1997 ident: B17 article-title: The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes publication-title: Nat Genet doi: 10.1038/ng0397-293 – volume: 64 year: 2015 ident: B34 article-title: Viral infection of engrafted human islets leads to diabetes publication-title: Diabetes doi: 10.2337/db14-1020 – volume: 22 year: 2016 ident: B8 article-title: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes publication-title: Nat Med doi: 10.1038/nm.4203 – volume: 104 start-page: 67 year: 1999 ident: B45 article-title: Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release publication-title: J Clin Invest doi: 10.1172/JCI6438 – volume: 130 year: 2020 ident: B52 article-title: Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression publication-title: J Clin Invest doi: 10.1172/JCI126595 – volume: 58 year: 2015 ident: B50 article-title: Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms publication-title: Diabetologia doi: 10.1007/s00125-015-3669-6 – volume: 81 start-page: 68 year: 2017 ident: B25 article-title: Alpha cells, the main source of IL-1beta in human pancreas publication-title: J Autoimmun doi: 10.1016/j.jaut.2017.03.006 – volume: 214 start-page: 108394 year: 2020 ident: B27 article-title: IL-4R is expressed on alpha and beta cells of human pancreata publication-title: Clin Immunol doi: 10.1016/j.clim.2020.108394 – volume: 29 start-page: 3916 year: 2019 ident: B20 article-title: Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway publication-title: Cell Rep doi: 10.1016/j.celrep.2019.11.056 – volume: 3 year: 2018 ident: B4 article-title: Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors publication-title: Sci Immunol doi: 10.1126/sciimmunol.aao4013 – volume: 11 year: 2011 ident: B11 article-title: Towards a systems understanding of MHC class I and MHC class II antigen presentation publication-title: Nat Rev Immunol doi: 10.1038/nri3084 – volume: 28 start-page: 946 year: 2018 ident: B9 article-title: Conventional and Neo-antigenic Peptides Presented by beta Cells Are Targeted by Circulating Naive CD8+ T Cells in Type 1 Diabetic and Healthy Donors publication-title: Cell Metab doi: 10.1016/j.cmet.2018.07.007 – volume: 211 start-page: 108320 year: 2020 ident: B24 article-title: IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes publication-title: Clin Immunol doi: 10.1016/j.clim.2019.108320 – volume: 50 year: 2001 ident: B47 article-title: gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1 publication-title: Diabetes doi: 10.2337/diabetes.50.12.2744 – volume: 51 year: 2002 ident: B16 article-title: Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes publication-title: Diabetes doi: 10.2337/diabetes.51.5.1383 – volume: 66 year: 2017 ident: B22 article-title: Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes publication-title: Diabetes doi: 10.2337/db16-1025 – volume: 61 year: 2012 ident: B33 article-title: Cytokine and chemokine production by human pancreatic islets upon enterovirus infection publication-title: Diabetes doi: 10.2337/db11-1547 – volume: 11 year: 2020 ident: B38 article-title: Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2020.00630 – volume: 36 year: 2018 ident: B46 article-title: PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-alpha and-gamma via IRF1 induction publication-title: EBioMedicine doi: 10.1016/j.ebiom.2018.09.040 – volume: 8 year: 2017 ident: B13 article-title: CD4(+) T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8(+) T Cell Function in the Pancreas publication-title: Front Immunol doi: 10.3389/fimmu.2017.02001 – volume: 59 year: 2010 ident: B3 article-title: Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers publication-title: Diabetes doi: 10.2337/db09-1486 – volume: 105 year: 2008 ident: B26 article-title: Interleukin-6 regulates pancreatic alpha-cell mass expansion publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0801059105 – volume: 57 year: 2010 ident: B37 article-title: Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes publication-title: Endocrine J doi: 10.1507/endocrj.K10E-076 – volume: 174 year: 2005 ident: B40 article-title: Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics publication-title: J Immunol doi: 10.4049/jimmunol.174.5.2746 – volume: 64 year: 2015 ident: B6 article-title: beta-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure publication-title: Diabetes doi: 10.2337/db14-0332 – volume: 65 year: 2016 ident: B43 article-title: Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes publication-title: Diabetes doi: 10.2337/db16-0616 – volume: 6 year: 2020 ident: B15 article-title: The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes publication-title: Sci Adv doi: 10.1126/sciadv.abc5586 – volume: 60 year: 2017 ident: B32 article-title: Interferon-alpha mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-016-4201-3 – volume: 197 year: 2003 ident: B31 article-title: Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells publication-title: J Exp Med doi: 10.1084/jem.20021378 – volume: 59 year: 2016 ident: B30 article-title: Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-016-4067-4 – volume: 55 year: 2012 ident: B49 article-title: Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-012-2604-3 – volume: 152 year: 2005 ident: B48 article-title: Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines publication-title: Eur J Endocrinol doi: 10.1530/eje.1.01856 |
| SSID | ssj0000401998 |
| Score | 2.4201064 |
| SecondaryResourceType | review_article |
| Snippet | Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 606434 |
| SubjectTerms | autoreactive CD8 T cells beta cells cytokines Endocrinology human pancreas type 1 diabetes |
| Title | New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33469446 https://www.proquest.com/docview/2479419698 https://pubmed.ncbi.nlm.nih.gov/PMC7813992 https://doaj.org/article/0babfa0cc6494912963122321b27a014 |
| Volume | 11 |
| WOSCitedRecordID | wos000608463200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-2392 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000401998 issn: 1664-2392 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-2392 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000401998 issn: 1664-2392 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fi9QwEA56iPgi5-_qeUTwSVgvTdIkfbzbu0PBO0RO2BcJSZpyi0sq157gi3-7M2lv2RXRF19KaFMaJpOZ-ZLpN4S8NpWvTAORW9N4hSXM3Kz2YAwlk5L7SkjtM2X-B31-bhaL-uNGqS_MCRvpgUfBHTDvfOtYCAp5VMA7KVGCS-Ol59qxXMKaM11vgKlsgwE2AJAYjzEBhdUHbUwN_uzH2VuFblhuOaLM1_-nIPP3XMkN53O6S-5PUSM9HEf7gNyK6SG5ezadiz8iX8BW0fepR6TdQ2PoKAR29FO3irRr6SESFUSXTRudHxt6QedxteqpSw2d_xi6r5j8TpeJ5j19iuCUlnTKlukfk8-nJxfzd7OpcMIsSFUNM-1U7cCIORADrDEnwK37ECVS3YfSy8Yw13jT1l4oUyrHeeugDWDJaCE4E0_ITupSfEaoNKE0jpsxdlEGeoWqFLr1ijVKuoKwGynaMLGKY3GLlQV0gYK3WfAWBW9HwRfkzfqVbyOlxt86H-HUrDsiG3a-ATpiJx2x_9KRgry6mVgLqwePRFyK3XVvORLsI0OQKcjTcaLXnxJCqhrQckH0lgpsjWX7SVpeZoZubUok_H3-Pwb_gtzjmEeD2z7VHtkZrq7jS3InfB-W_dU-ua0XZj8rP1zPfp78AkfMBEs |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=New+Insights+Into+the+Role+of+Autoreactive+CD8+T+Cells+and+Cytokines+in+Human+Type+1+Diabetes&rft.jtitle=Frontiers+in+endocrinology+%28Lausanne%29&rft.au=Bender%2C+Christine&rft.au=Rajendran%2C+Sakthi&rft.au=von+Herrath%2C+Matthias+G&rft.date=2021-01-05&rft.issn=1664-2392&rft.eissn=1664-2392&rft.volume=11&rft.spage=606434&rft_id=info:doi/10.3389%2Ffendo.2020.606434&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2392&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2392&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2392&client=summon |