Nocebo-Hypothesis Cognitive Behavioral Therapy (NH-CBT) for Persons With Functional Neurological Symptoms (Motor Type): Design and Implementation of a Randomized Active-Controlled Trial

Introduction: Functional Neurological Symptom Disorders (FNSD) are associated with high levels of disability and immense direct and indirect health costs. An innovative interdisciplinary rehabilitation approach for individuals with functional neurological symptoms of motor type–Nocebo-Hypothesis Cog...

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Vydáno v:Frontiers in neurology Ročník 11; s. 586359
Hlavní autoři: Richardson, Matt, Kleinstäuber, Maria, Wong, Dana
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 07.12.2020
Témata:
cognitive behavioral therapy
functional neurological symptom disorder
movement retraining
Neurology
physical therapy
predictive coding model
psychogenic movement disorder
cognitive behavioral therapy
nocebo effect
psychogenic movement disorder
functional neurological symptom disorder
movement retraining
physical therapy
predictive coding model
randomized controlled trial
ISSN:1664-2295, 1664-2295
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Shrnutí:Introduction: Functional Neurological Symptom Disorders (FNSD) are associated with high levels of disability and immense direct and indirect health costs. An innovative interdisciplinary rehabilitation approach for individuals with functional neurological symptoms of motor type–Nocebo-Hypothesis Cognitive Behavioral Therapy (NH-CBT)—combines CBT and movement retraining with video feedback embedded in a comprehensive explanatory model of the etiology of FNSD. Methods: This protocol describes the development and implementation of a phase II, parallel group, randomized controlled trial with blinded outcome assessors to compare the efficacy of NH-CBT with an active control condition (supportive counseling and movement retraining). Individuals meeting diagnostic criteria of an FNSD or psychogenic movement disorder will be randomly assigned to one of the 8-week interventions. Self-report scales of motor and other physical symptoms, symptom-related psychological variables, and assessor ratings of participants' mobility will be administered at baseline, and at 8- and 16-week follow-up. Adverse events will be monitored across all sessions and therapeutic alliance will be measured at the end of therapy. The primary statistical analysis will test the hypothesis that NH-CBT is more effective than the control intervention at the 8-week follow-up. Discussion: The therapeutic strategies of NH-CBT are theory-driven by assumptions of the predictive coding model of the etiology of FNSD. Strengths and limitations of this trial will be discussed. Trial registration : Australian New Zealand Clinical Trials Registry (ANZCTR; identifier: ACTRN12620000550909).
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Edited by: Noah D. Silverberg, University of British Columbia, Canada
This article was submitted to Neurorehabilitation, a section of the journal Frontiers in Neurology
Reviewed by: Glenn Nielsen, St George's University of London, United Kingdom; Nicola O'Connell, Trinity College Dublin, Ireland; Matthew J. Burke, University of Toronto, Canada
These authors have contributed equally to this work and share first authorship
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.586359