IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice

Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells. Here, we tested the impact of a...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 11; p. 596772
Main Authors:	Link, Christopher W.M., Rau, Christina N., Udoye, Christopher C., Ragab, Mohab, Korkmaz, Rabia Ü., Comdühr, Sara, Clauder, Ann-Katrin, Lindemann, Timo, Frehse, Britta, Hofmann, Katharina, Almeida, Larissa N., Laumonnier, Yves, Beidaq, Asmaa El, Finkelman, Fred D., Manz, Rudolf A.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 11.12.2020
Subjects:	Allergens - immunology anaphylaxis Anaphylaxis - etiology Anaphylaxis - metabolism Animals Chickens Cytokines - metabolism Disease Models, Animal Egg White - adverse effects Female Food - adverse effects food allergy Food Hypersensitivity - immunology IFN-γ IL-2 Immunization Immunoglobulin E - blood Immunoglobulin E - immunology Immunology Interferon-gamma - metabolism Interleukin-2 - agonists Mice murine model IFN-γ IL-2 anaphylaxis murine model food allergy
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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