ImmunosuppressiveTherapies Differently Modulate Humoral- and T-Cell-Specific Responses to COVID-19 mRNA Vaccine in Rheumatoid Arthritis Patients

To assess in rheumatoid arthritis (RA) patients, treated with different immunosuppressive therapies, the induction of SARS-CoV-2-specific immune response after vaccination in terms of anti-region-binding-domain (RBD)-antibody- and T-cell-specific responses against spike, and the vaccine safety in te...

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Veröffentlicht in:	Frontiers in immunology Jg. 12; S. 740249
Hauptverfasser:	Picchianti-Diamanti, Andrea, Aiello, Alessandra, Laganà, Bruno, Agrati, Chiara, Castilletti, Concetta, Meschi, Silvia, Farroni, Chiara, Lapa, Daniele, Najafi Fard, Saeid, Cuzzi, Gilda, Cimini, Eleonora, Grassi, Germana, Vanini, Valentina, Di Rosa, Roberta, Salemi, Simonetta, Nalli, Gabriele, Salmi, Andrea, Repele, Federica, Altera, Anna Maria Gerarda, Maffongelli, Gaetano, Palazzolo, Claudia, Vita, Serena, Leone, Sara, Puro, Vincenzo, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Nicastri, Emanuele, Goletti, Delia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 14.09.2021
Schlagworte:	Aged Antibodies, Viral - immunology antibody response Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology COVID-19 COVID-19 - prevention & control COVID-19 Vaccines - immunology Female Humans Immunology Immunotherapy - adverse effects Interferon-gamma - immunology Lymphocyte Count Male Middle Aged mRNA vaccine mRNA Vaccines rheumatoid arthritis SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - immunology T cell response T-Lymphocytes - cytology T-Lymphocytes - immunology Vaccines, Synthetic - immunology whole blood COVID-19 antibody response T cell response biological therapy whole blood DMARD (disease modifying anti-rheumatic drug) rheumatoid arthritis mRNA vaccine
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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