Lack of Cell Cycle Inhibitor p21 and Low CD4+ T Cell Suppression in Newborns After Exposure to IFN-β

Type I IFNs, such as interferon alpha and interferon beta, are key regulators of the adaptive immune response during infectious diseases. Type I IFNs are induced upon infection, bind interferon α/β receptors on T-cells and activate intracellular pathways. The activating and inhibitory consequences o...

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Bibliographic Details

Published in:	Frontiers in immunology Vol. 12; p. 652965
Main Authors:	Jans, Jop, Unger, Wendy W., Raeven, Elisabeth A. M., Simonetti, Elles R., Eleveld, Marc J., de Groot, Ronald, de Jonge, Marien I., Ferwerda, Gerben
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 12.04.2021
Subjects:	CD4 T cells immunity Immunology interferon beta newborns proliferation respiratory syncytial virus interferon beta cyclic-dependent kinase inhibitor/p21 proliferation cell cycle CD4 T cells newborns immunity respiratory syncytial virus
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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