Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study

Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex ( Capra pyrenaica ) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. Howe...

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Veröffentlicht in:Frontiers in veterinary science Jg. 9; S. 830157
Hauptverfasser: Moroni, Barbara, Granados Torres, José Enrique, López-Olvera, Jorge Ramón, Espinosa Cerrato, José, Ráez Bravo, Arián, Mentaberre, Gregorio, Fandos, Paulino, Pazzi, Marco, Romagnoli, Monica, Gardini, Giulia, Rossi, Luca, Valldeperes, Marta, Serrano, Emmanuel, Ramos, Blanca, Odore, Rosangela
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 01.04.2022
Schlagworte:
Iberian ibex
ivermectin
medicated feed
sarcoptic mange
treatment
Veterinary Science
wildlife
treatment
medicated feed
Iberian ibex
ivermectin
sarcoptic mange
wildlife
ISSN:2297-1769, 2297-1769
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Zusammenfassung:Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex ( Capra pyrenaica ) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. However, there are no data on ivermectin (IVM) pharmacokinetics in this wild caprine, and the treatment through medicated feed is not endorsed by evidence on its effectiveness. The aim of this study is to determine the pharmacokinetic profile of IVM in plasma samples of ibexes after the experimental oral administration of IVM, using high performance liquid chromatography (HPLC) with automated solid phase extraction and fluorescence detection. A dose of 500 μg of IVM per body weight was orally administered in a feed bolus to nine healthy adult ibexes (seven males and two females). Blood samples were collected by jugular venipuncture into heparin-coated tubes at day 1, 2, 3, 4, 7, 10, 15, and 45 post-administration (dpa). The highest plasma concentration of IVM (Cmax = 3.4 ng/ml) was detected 24 h after the oral administration (T1), followed by a rapid decrease during the first week post-administration. Our results reveal that plasma IVM concentration drops drastically within 5 days of ingestion, questioning the effectiveness of a single in-feed dose of this drug to control sarcoptic mange. To the best of our knowledge, this is the first study on plasma availability of oral IVM in ibexes and in any wild ungulate species.
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Marta Valldeperes orcid.org/0000-0002-6178-3147
José Enrique Granados Torres orcid.org/0000-0002-9787-9896
Blanca Ramos orcid.org/0000-0003-1417-2455
Edited by: J. Alberto Montoya-Alonso, University of Las Palmas de Gran Canaria, Spain
Rosangela Odore orcid.org/0000-0001-8529-2003
Jorge Ramón López Olvera orcid.org/0000-0002-2999-3451
Marco Pazzi orcid.org/0000-0002-9763-8785
ORCID: Barbara Moroni orcid.org/0000-0003-1478-8436
Reviewed by: Vincenzo Veneziano, University of Naples Federico II, Italy; Cristóbal Briceño, University of Chile, Chile; Juan Alberto Corbera, University of Las Palmas de Gran Canaria, Spain
Monica Romagnoli orcid.org/0000-0003-1119-4229
José Espinosa Cerrato orcid.org/0000-0002-9036-1402
This article was submitted to Parasitology, a section of the journal Frontiers in Veterinary Science
Paulino Fandos orcid.org/0000-0002-9607-8931
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2022.830157