Digital Microfluidic Platform for Multiplexing Enzyme Assays: Implications for Lysosomal Storage Disease Screening in Newborns

Newborn screening for lysosomal storage diseases (LSDs) has been gaining considerable interest owing to the availability of enzyme replacement therapies. We present a digital microfluidic platform to perform rapid, multiplexed enzymatic analysis of acid α-glucosidase (GAA) and acid α-galactosidase t...

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Vydané v:	Clinical chemistry (Baltimore, Md.) Ročník 57; číslo 10; s. 1444 - 1451
Hlavní autori:	Sista, Ramakrishna S, Eckhardt, Allen E, Wang, Tong, Graham, Carrie, Rouse, Jeremy L, Norton, Scott M, Srinivasan, Vijay, Pollack, Michael G, Tolun, Adviye A, Bali, Deeksha, Millington, David S, Pamula, Vamsee K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Washington, DC American Association for Clinical Chemistry 01.10.2011 Oxford University Press
Predmet:	alpha-Galactosidase - blood alpha-Glucosidases - blood Analytical, structural and metabolic biochemistry Automation Biological and medical sciences Clinical Enzyme Tests - instrumentation Disease Enzymatic activity Fabry Disease - diagnosis Fluorometry Fundamental and applied biological sciences. Psychology Genetics Glycogen Storage Disease Type II - diagnosis Humans Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Lab-On-A-Chip Devices Medical sciences Medical screening Methods Microfluidic Analytical Techniques - instrumentation Molecular biophysics Neonatal Screening Public health Human Assay Multiplexing Newborn Enzyme Clinical biology Biochemistry Molecular biology Medical screening Lysosomal storage disease
ISSN:	0009-9147, 1530-8561, 1530-8561
On-line prístup:	Získať plný text
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