Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment

An accurate biomarker is urgently needed to monitor the response to treatment in patients with pulmonary tuberculosis. The Xpert MTB/RIF assay is a commercially available real-time PCR that can be used to detect Mycobacterium-tuberculosis-specific DNA sequences in sputum samples. We therefore evalua...

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Veröffentlicht in:	The lancet respiratory medicine Jg. 1; H. 6; S. 462
Hauptverfasser:	Friedrich, Sven O, Rachow, Andrea, Saathoff, Elmar, Singh, Kasha, Mangu, Chacha D, Dawson, Rodney, Phillips, Patrick Pj, Venter, Amour, Bateson, Anna, Boehme, Catharina C, Heinrich, Norbert, Hunt, Robert D, Boeree, Martin J, Zumla, Alimuddin, McHugh, Timothy D, Gillespie, Stephen H, Diacon, Andreas H, Hoelscher, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.08.2013
Schlagworte:	Adult Antitubercular Agents - therapeutic use Biological Assay - methods Biomarkers - metabolism DNA, Bacterial - isolation & purification Female Humans Male Middle Aged Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Real-Time Polymerase Chain Reaction - methods Recurrence Sensitivity and Specificity Sputum - microbiology Treatment Outcome Tuberculosis, Pulmonary - drug therapy
ISSN:	2213-2600
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