EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to o...

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Vydáno v:	Frontiers in immunology Ročník 12; s. 634416
Hlavní autoři:	Luft, Thomas, Wendtner, Clemens-Martin, Kosely, Florentina, Radujkovic, Aleksandar, Benner, Axel, Korell, Felix, Kihm, Lars, Bauer, Matthias F., Dreger, Peter, Merle, Uta
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Media S.A 23.06.2021
Témata:	Adolescent Adult Aged Aged, 80 and over angiopoietin-2 (Ang-2) Biomarkers - metabolism COVID-19 - diagnosis COVID-19 - mortality EASIX endothelial activation and stress index Endothelial Cells - physiology Female Hematopoietic Stem Cell Transplantation Hospitalization Humans Immunology Male Middle Aged Prognosis Prospective Studies Respiration, Artificial SARS-CoV-2 - physiology SARS-CoV2 (COVID- 19) Severity of Illness Index soluble thrombomodulin suppressor of tumorigenicity 2 (ST2) Survival Analysis Transplantation, Homologous Treatment Outcome Young Adult angiopoietin-2 (Ang-2) soluble thrombomodulin prediction of outcome endothelial activation and stress index suppressor of tumorigenicity 2 (ST2) EASIX SARS-CoV2 (COVID- 19)
ISSN:	1664-3224, 1664-3224
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Abstract	The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to optimize allocation of limited resources. Endothelial activation and stress index (EASIX) is a validated predictor of endothelial complications and outcome after allogeneic stem cell transplantation. Aim of this study was to test if EASIX could predict life-threatening complications in patients with COVID-19. SARS-CoV-2-positive, hospitalized patients were enrolled onto a prospective non-interventional register study (n=100). Biomarkers were assessed at hospital admission. Primary endpoint was severe course of disease (mechanical ventilation and/or death, V/D). Results were validated in 126 patients treated in two independent institutions. EASIX at admission was a strong predictor of severe course of the disease (odds ratio for a two-fold change 3.4, 95%CI 1.8-6.3, p<0.001), time to V/D (hazard ratio (HR) for a two-fold change 2.0, 95%CI 1.5-2.6, p<0.001) as well as survival (HR for a two-fold change 1.7, 95%CI 1.2-2.5, p=0.006). The effect was retained in multivariable analysis adjusting for age, gender, and comorbidities and could be validated in the independent cohort. At hospital admission EASIX correlated with increased suppressor of tumorigenicity-2, soluble thrombomodulin, angiopoietin-2, CXCL8, CXCL9 and interleukin-18, but not interferon-alpha. EASIX is a validated predictor of COVID19 outcome and an easy-to-access tool to segregate patients in need for intensive surveillance.
AbstractList	The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to optimize allocation of limited resources. Endothelial activation and stress index (EASIX) is a validated predictor of endothelial complications and outcome after allogeneic stem cell transplantation. Aim of this study was to test if EASIX could predict life-threatening complications in patients with COVID-19.BACKGROUNDThe coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to optimize allocation of limited resources. Endothelial activation and stress index (EASIX) is a validated predictor of endothelial complications and outcome after allogeneic stem cell transplantation. Aim of this study was to test if EASIX could predict life-threatening complications in patients with COVID-19.SARS-CoV-2-positive, hospitalized patients were enrolled onto a prospective non-interventional register study (n=100). Biomarkers were assessed at hospital admission. Primary endpoint was severe course of disease (mechanical ventilation and/or death, V/D). Results were validated in 126 patients treated in two independent institutions.METHODSSARS-CoV-2-positive, hospitalized patients were enrolled onto a prospective non-interventional register study (n=100). Biomarkers were assessed at hospital admission. Primary endpoint was severe course of disease (mechanical ventilation and/or death, V/D). Results were validated in 126 patients treated in two independent institutions.EASIX at admission was a strong predictor of severe course of the disease (odds ratio for a two-fold change 3.4, 95%CI 1.8-6.3, p<0.001), time to V/D (hazard ratio (HR) for a two-fold change 2.0, 95%CI 1.5-2.6, p<0.001) as well as survival (HR for a two-fold change 1.7, 95%CI 1.2-2.5, p=0.006). The effect was retained in multivariable analysis adjusting for age, gender, and comorbidities and could be validated in the independent cohort. At hospital admission EASIX correlated with increased suppressor of tumorigenicity-2, soluble thrombomodulin, angiopoietin-2, CXCL8, CXCL9 and interleukin-18, but not interferon-alpha.RESULTSEASIX at admission was a strong predictor of severe course of the disease (odds ratio for a two-fold change 3.4, 95%CI 1.8-6.3, p<0.001), time to V/D (hazard ratio (HR) for a two-fold change 2.0, 95%CI 1.5-2.6, p<0.001) as well as survival (HR for a two-fold change 1.7, 95%CI 1.2-2.5, p=0.006). The effect was retained in multivariable analysis adjusting for age, gender, and comorbidities and could be validated in the independent cohort. At hospital admission EASIX correlated with increased suppressor of tumorigenicity-2, soluble thrombomodulin, angiopoietin-2, CXCL8, CXCL9 and interleukin-18, but not interferon-alpha.EASIX is a validated predictor of COVID19 outcome and an easy-to-access tool to segregate patients in need for intensive surveillance.CONCLUSIONEASIX is a validated predictor of COVID19 outcome and an easy-to-access tool to segregate patients in need for intensive surveillance. The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to optimize allocation of limited resources. Endothelial activation and stress index (EASIX) is a validated predictor of endothelial complications and outcome after allogeneic stem cell transplantation. Aim of this study was to test if EASIX could predict life-threatening complications in patients with COVID-19. SARS-CoV-2-positive, hospitalized patients were enrolled onto a prospective non-interventional register study (n=100). Biomarkers were assessed at hospital admission. Primary endpoint was severe course of disease (mechanical ventilation and/or death, V/D). Results were validated in 126 patients treated in two independent institutions. EASIX at admission was a strong predictor of severe course of the disease (odds ratio for a two-fold change 3.4, 95%CI 1.8-6.3, p<0.001), time to V/D (hazard ratio (HR) for a two-fold change 2.0, 95%CI 1.5-2.6, p<0.001) as well as survival (HR for a two-fold change 1.7, 95%CI 1.2-2.5, p=0.006). The effect was retained in multivariable analysis adjusting for age, gender, and comorbidities and could be validated in the independent cohort. At hospital admission EASIX correlated with increased suppressor of tumorigenicity-2, soluble thrombomodulin, angiopoietin-2, CXCL8, CXCL9 and interleukin-18, but not interferon-alpha. EASIX is a validated predictor of COVID19 outcome and an easy-to-access tool to segregate patients in need for intensive surveillance. BackgroundThe coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to optimize allocation of limited resources. Endothelial activation and stress index (EASIX) is a validated predictor of endothelial complications and outcome after allogeneic stem cell transplantation. Aim of this study was to test if EASIX could predict life-threatening complications in patients with COVID-19.MethodsSARS-CoV-2-positive, hospitalized patients were enrolled onto a prospective non-interventional register study (n=100). Biomarkers were assessed at hospital admission. Primary endpoint was severe course of disease (mechanical ventilation and/or death, V/D). Results were validated in 126 patients treated in two independent institutions.ResultsEASIX at admission was a strong predictor of severe course of the disease (odds ratio for a two-fold change 3.4, 95%CI 1.8-6.3, p<0.001), time to V/D (hazard ratio (HR) for a two-fold change 2.0, 95%CI 1.5-2.6, p<0.001) as well as survival (HR for a two-fold change 1.7, 95%CI 1.2-2.5, p=0.006). The effect was retained in multivariable analysis adjusting for age, gender, and comorbidities and could be validated in the independent cohort. At hospital admission EASIX correlated with increased suppressor of tumorigenicity-2, soluble thrombomodulin, angiopoietin-2, CXCL8, CXCL9 and interleukin-18, but not interferon-alpha.ConclusionEASIX is a validated predictor of COVID19 outcome and an easy-to-access tool to segregate patients in need for intensive surveillance.
Author	Benner, Axel Bauer, Matthias F. Dreger, Peter Kosely, Florentina Wendtner, Clemens-Martin Radujkovic, Aleksandar Luft, Thomas Merle, Uta Korell, Felix Kihm, Lars
AuthorAffiliation	2 Munich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilians University (LMU) , Munich , Germany 7 Department of Internal Medicine IV, University of Heidelberg , Heidelberg , Germany 1 Department of Internal Medicine V, University of Heidelberg , Heidelberg , Germany 4 Division of Biostatistics, German Cancer Research Center , Heidelberg , Germany 6 Institute of Laboratory Diagnostics, Hygiene and Transfusion Medicine, Hospital Ludwigshafen , Ludwigshafen , Germany 3 Medical Department B, Hospital Ludwigshafen , Ludwigshafen , Germany 5 Department of Internal Medicine I, University of Heidelberg , Heidelberg , Germany
AuthorAffiliation_xml	– name: 2 Munich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilians University (LMU) , Munich , Germany – name: 4 Division of Biostatistics, German Cancer Research Center , Heidelberg , Germany – name: 7 Department of Internal Medicine IV, University of Heidelberg , Heidelberg , Germany – name: 1 Department of Internal Medicine V, University of Heidelberg , Heidelberg , Germany – name: 3 Medical Department B, Hospital Ludwigshafen , Ludwigshafen , Germany – name: 5 Department of Internal Medicine I, University of Heidelberg , Heidelberg , Germany – name: 6 Institute of Laboratory Diagnostics, Hygiene and Transfusion Medicine, Hospital Ludwigshafen , Ludwigshafen , Germany
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Cites_doi	10.1016/j.cell.2020.02.052 10.1016/j.ebiom.2019.10.024 10.1111/j.0006-341X.2000.00337.x 10.1002/jmv.25915 10.1002/bimj.200610301 10.1038/s41408-019-0247-z 10.1016/j.ijid.2020.03.017 10.1182/blood-2011-02-334821 10.1186/s13054-020-2833-7 10.3324/haematol.10699 10.1038/s41577-020-0343-0 10.1093/cvr/cvaa106 10.1016/j.thromres.2020.04.014 10.1056/NEJMoa1213299 10.1016/j.jacc.2008.09.027 10.1016/j.eclinm.2020.100449 10.1016/j.amjcard.2015.01.034 10.1016/j.jacc.2020.04.031 10.1038/s41409-019-0703-1 10.3390/cancers12102789 10.1182/bloodadvances.2019032268 10.1007/s10456-020-09730-0 10.1016/S2352-3026(17)30108-4 10.1038/bmt.2017.119 10.1093/infdis/jiaa528 10.1161/CIRCULATIONAHA.120.047549 10.1161/CIRCULATIONAHA.120.047419 10.3324/haematol.2011.061051 10.1093/cvr/cvaa230 10.1186/s12885-020-07317-y 10.3389/fimmu.2021.648004 10.1016/S0140-6736(20)31129-6 10.1016/j.bbmt.2020.01.028 10.1007/s002770050364 10.1001/jamacardio.2020.0950 10.1016/S0140-6736(20)30566-3 10.1101/2020.04.29.20085878 10.1001/jama.2020.1585 10.1177/2045894020966547 10.1016/S0140-6736(20)30937-5 10.1016/S0140-6736(20)31103-X 10.1038/s41408-021-00434-2 10.1111/j.1541-0420.2008.00995.x 10.1186/s40001-020-00432-3 10.1080/09537104.2020.1762852 10.7326/M20-0504 10.1016/j.bbmt.2012.09.018 10.1017/S095026882000179X 10.1515/cclm-2020-1062 10.1002/bimj.200810443
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Copyright	Copyright © 2021 Luft, Wendtner, Kosely, Radujkovic, Benner, Korell, Kihm, Bauer, Dreger and Merle. Copyright © 2021 Luft, Wendtner, Kosely, Radujkovic, Benner, Korell, Kihm, Bauer, Dreger and Merle 2021 Luft, Wendtner, Kosely, Radujkovic, Benner, Korell, Kihm, Bauer, Dreger and Merle
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Keywords	angiopoietin-2 (Ang-2) soluble thrombomodulin prediction of outcome endothelial activation and stress index suppressor of tumorigenicity 2 (ST2) EASIX SARS-CoV2 (COVID- 19)
Language	English
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Helena Stabile, Sapienza University of Rome, Italy This article was submitted to Cytokines and Soluble Mediators in Immunity, a section of the journal Frontiers in Immunology Reviewed by: Saikat Majumder, University of Pittsburgh, United States; Tatiani Uceli Maioli, Federal University of Minas Gerais, Brazil
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References	Radujkovic (B32) 2019; 49 Luft (B24) 2020; 55 Liu (B18) 2020; 142 Heagerty (B38) 2000; 56 Dai (B30) 2021; 11 Bikdeli (B9) 2020; 75 Shouval (B25) 2019; 3 Gerds (B37) 2006; 48 Varma (B26) 2020; 3 Wang (B2) 2020; 323 Campbell (B17) 2020 Luft (B23) 2017; 4 Dietrich (B29) 2013; 19 Viner (B8) 2020; 395 Ciceri (B15) 2020; 22 Radujkovic (B31) 2020; 12 Yang (B5) 2020; 94 Shi (B35) 2020; 24 Guzik (B3) 2020; 116 Smadja (B16) 2020; 23 Shi (B4) 2020; 5 Paniz-Mondolfi (B11) 2020; 92 Gerds (B36) 2008; 50 Salamanna (B43) 2020; 31 Ruutu (B21) 2007; 92 Zeisbrich (B20) 2017; 52 Pascual-Figal (B47) 2015; 115 Mancuso (B51) 2020; 18 Evans (B52) 2020; 116 Ou (B41) 2020; 148 Luft (B19) 2011; 118 Song (B28) 2020; 20 Contoli (B33) 2021; 12 Panteghini (B42) 2020; 58 Vander Lugt (B49) 2013; 369 Jiang (B22) 2020; 92 Pine (B34) 2020; 10 Hothorn (B39) 2008; 64 Andrulis (B48) 2012; 97 Lauer (B1) 2020; 172 Zhou (B6) 2020; 395 Verdoni (B7) 2020; 395 Varga (B13) 2020; 35 Bartunek (B46) 2008; 52 Teuwen (B12) 2020; 20 Hoffmann (B14) 2020; 181 Nurnberger (B45) 1998; 76 Wendel Garcia (B44) 2020; 25 Guervilly (B50) 2020; 222 Escher (B10) 2020; 190 Merz (B27) 2019; 9 Ghahramani (B40) 2020; 25
References_xml	– volume: 181 start-page: 271 year: 2020 ident: B14 article-title: SARS-Cov-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor publication-title: Cell doi: 10.1016/j.cell.2020.02.052 – volume: 49 year: 2019 ident: B32 article-title: Interleukin-18 and Outcome After Allogeneic Stem Cell Transplantation: A Retrospective Cohort Study publication-title: EBioMedicine doi: 10.1016/j.ebiom.2019.10.024 – volume: 56 year: 2000 ident: B38 article-title: Time-Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker publication-title: Biometrics doi: 10.1111/j.0006-341X.2000.00337.x – volume: 92 start-page: 699 year: 2020 ident: B11 article-title: Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2) publication-title: J Med Virol doi: 10.1002/jmv.25915 – volume: 48 year: 2006 ident: B37 article-title: Consistent Estimation of the Expected Brier Score in General Survival Models With Right-Censored Event Times publication-title: Biom J doi: 10.1002/bimj.200610301 – volume: 9 start-page: 85 year: 2019 ident: B27 article-title: EASIX for Prediction of Survival in Lower-Risk Myelodysplastic Syndromes publication-title: Blood Cancer J doi: 10.1038/s41408-019-0247-z – volume: 94 year: 2020 ident: B5 article-title: Prevalence of Comorbidities and Its Effects in Coronavirus Disease 2019 Patients: A Systematic Review and Meta-Analysis publication-title: Int J Infect Dis doi: 10.1016/j.ijid.2020.03.017 – volume: 118 year: 2011 ident: B19 article-title: Steroid-Refractory GVHD: T-Cell Attack Within a Vulnerable Endothelial System publication-title: Blood doi: 10.1182/blood-2011-02-334821 – volume: 24 start-page: 108 year: 2020 ident: B35 article-title: Host Susceptibility to Severe COVID-19 and Establishment of a Host Risk Score: Findings of 487 Cases Outside Wuhan publication-title: Crit Care doi: 10.1186/s13054-020-2833-7 – volume: 92 start-page: 95 year: 2007 ident: B21 article-title: Diagnostic Criteria for Hematopoietic Stem Cell Transplant-Associated Microangiopathy: Results of a Consensus Process by an International Working Group publication-title: Haematologica doi: 10.3324/haematol.10699 – volume: 20 year: 2020 ident: B12 article-title: Covid-19: The Vasculature Unleashed publication-title: Nat Rev Immunol doi: 10.1038/s41577-020-0343-0 – volume: 116 year: 2020 ident: B3 article-title: Covid-19 and the Cardiovascular System: Implications for Risk Assessment, Diagnosis, and Treatment Options publication-title: Cardiovasc Res doi: 10.1093/cvr/cvaa106 – volume: 190 start-page: 62 year: 2020 ident: B10 article-title: Severe COVID-19 Infection Associated With Endothelial Activation publication-title: Thromb Res doi: 10.1016/j.thromres.2020.04.014 – volume: 369 year: 2013 ident: B49 article-title: ST2 as a Marker for Risk of Therapy-Resistant Graft-Versus-Host Disease and Death publication-title: N Engl J Med doi: 10.1056/NEJMoa1213299 – volume: 52 year: 2008 ident: B46 article-title: Nonmyocardial Production of ST2 Protein in Human Hypertrophy and Failure Is Related to Diastolic Load publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2008.09.027 – volume: 25 start-page: 100449 year: 2020 ident: B44 article-title: Prognostic Factors Associated With Mortality Risk and Disease Progression in 639 Critically Ill Patients With COVID-19 in Europe: Initial Report of the International RISC-19-ICU Prospective Observational Cohort publication-title: EClinicalMedicine doi: 10.1016/j.eclinm.2020.100449 – volume: 115 start-page: 3B year: 2015 ident: B47 article-title: The Biology of ST2: The International St2 Consensus Panel publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2015.01.034 – volume: 75 year: 2020 ident: B9 article-title: Covid-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2020.04.031 – volume: 55 year: 2020 ident: B24 article-title: EASIX and Mortality After Allogeneic Stem Cell Transplantation publication-title: Bone Marrow Transplant doi: 10.1038/s41409-019-0703-1 – volume: 12 start-page: 2789 year: 2020 ident: B31 article-title: Interleukin-18 and Hematopoietic Recovery After Allogeneic Stem Cell Transplantation publication-title: Cancers (Basel) doi: 10.3390/cancers12102789 – volume: 3 year: 2019 ident: B25 article-title: External Validation and Comparison of Multiple Prognostic Scores in Allogeneic Hematopoietic Stem Cell Transplantation publication-title: Blood Adv doi: 10.1182/bloodadvances.2019032268 – volume: 23 year: 2020 ident: B16 article-title: Angiopoietin-2 as a Marker of Endothelial Activation Is a Good Predictor Factor for Intensive Care Unit Admission of COVID-19 Patients publication-title: Angiogenesis doi: 10.1007/s10456-020-09730-0 – volume: 4 year: 2017 ident: B23 article-title: EASIX in Patients With Acute Graft-Versus-Host Disease: A Retrospective Cohort Analysis publication-title: Lancet Haematol doi: 10.1016/S2352-3026(17)30108-4 – volume: 52 year: 2017 ident: B20 article-title: Transplant-Associated Thrombotic Microangiopathy Is an Endothelial Complication Associated With Refractoriness of Acute GvHD publication-title: Bone Marrow Transplant doi: 10.1038/bmt.2017.119 – volume: 22 start-page: 284 year: 2020 ident: B15 article-title: Microvascular COVID-19 Lung Vessels Obstructive Thromboinflammatory Syndrome (MicroCLOTS): An Atypical Acute Respiratory Distress Syndrome Working Hypothesis publication-title: Crit Care Resusc – volume: 222 year: 2020 ident: B50 article-title: Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe Covid-19 publication-title: J Infect Dis doi: 10.1093/infdis/jiaa528 – volume: 142 start-page: 68 year: 2020 ident: B18 article-title: The Science Underlying COVID-19: Implications for the Cardiovascular System publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.047549 – year: 2020 ident: B17 article-title: Will Complement Inhibition be the New Target in Treating Covid-19 Related Systemic Thrombosis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.047419 – volume: 97 year: 2012 ident: B48 article-title: Loss of Endothelial Thrombomodulin Predicts Response to Steroid Therapy and Survival in Acute Intestinal Graft-Versus-Host Disease publication-title: Haematologica doi: 10.3324/haematol.2011.061051 – volume: 116 year: 2020 ident: B52 article-title: Endothelial Dysfunction in COVID-19: A Position Paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science publication-title: Cardiovasc Res doi: 10.1093/cvr/cvaa230 – volume: 20 start-page: 803 year: 2020 ident: B28 article-title: Endothelial Activation and Stress Index (EASIX) Is a Reliable Predictor for Overall Survival in Patients With Multiple Myeloma publication-title: BMC Cancer doi: 10.1186/s12885-020-07317-y – volume: 12 year: 2021 ident: B33 article-title: Blood Interferon-Alpha Levels and Severity, Outcomes, and Inflammatory Profiles in Hospitalized Covid-19 Patients publication-title: Front Immunol doi: 10.3389/fimmu.2021.648004 – volume: 395 year: 2020 ident: B8 article-title: Kawasaki-Like Disease: Emerging Complication During the COVID-19 Pandemic publication-title: Lancet doi: 10.1016/S0140-6736(20)31129-6 – volume: 3 year: 2020 ident: B26 article-title: Endothelial Activation and Stress Index (EASIX) at Admission Predicts Fluid Overload in Recipients of Allogeneic Stem Cell Transplantation publication-title: Biol Blood Marrow Transplant doi: 10.1016/j.bbmt.2020.01.028 – volume: 76 year: 1998 ident: B45 article-title: Endothelial Dysfunction After Bone Marrow Transplantation: Increase of Soluble Thrombomodulin and PAI-1 in Patients With Multiple Transplant-Related Complications publication-title: Ann Hematol doi: 10.1007/s002770050364 – volume: 5 year: 2020 ident: B4 article-title: Association of Cardiac Injury With Mortality in Hospitalized Patients With Covid-19 in Wuhan, China publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2020.0950 – volume: 395 year: 2020 ident: B6 article-title: Clinical Course and Risk Factors for Mortality of Adult Inpatients With COVID-19 in Wuhan, China: A Retrospective Cohort Study publication-title: Lancet doi: 10.1016/S0140-6736(20)30566-3 – volume: 18 year: 2020 ident: B51 article-title: Circulating Endothelial Progenitors are Increased in Covid-19 Patients and Correlate With SARS-CoV-2 RNA in Severe Cases publication-title: J Thromb Haemost doi: 10.1101/2020.04.29.20085878 – volume: 323 year: 2020 ident: B2 article-title: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China publication-title: JAMA doi: 10.1001/jama.2020.1585 – volume: 10 start-page: 2045894020966547 year: 2020 ident: B34 article-title: Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19 publication-title: Pulm Circ doi: 10.1177/2045894020966547 – volume: 35 year: 2020 ident: B13 article-title: Endothelial Cell Infection and Endotheliitis in COVID-19 publication-title: Lancet doi: 10.1016/S0140-6736(20)30937-5 – volume: 395 year: 2020 ident: B7 article-title: An Outbreak of Severe Kawasaki-Like Disease at the Italian Epicentre of the SARS-CoV-2 Epidemic: An Observational Cohort Study publication-title: Lancet doi: 10.1016/S0140-6736(20)31103-X – volume: 11 start-page: 42 year: 2021 ident: B30 article-title: Polymorphisms in CXCR3 Ligands Predict Early CXCL9 Recovery and Severe Chronic GVHD publication-title: Blood Cancer J doi: 10.1038/s41408-021-00434-2 – volume: 64 year: 2008 ident: B39 article-title: Generalized Maximally Selected Statistics publication-title: Biometrics doi: 10.1111/j.1541-0420.2008.00995.x – volume: 25 start-page: 30 year: 2020 ident: B40 article-title: Laboratory Features of Severe vs. Non-Severe COVID-19 Patients in Asian Populations: A Systematic Review and Meta-Analysis publication-title: Eur J Med Res doi: 10.1186/s40001-020-00432-3 – volume: 31 year: 2020 ident: B43 article-title: Platelet Functions and Activities as Potential Hematologic Parameters Related to Coronavirus Disease 2019 (Covid-19) publication-title: Platelets doi: 10.1080/09537104.2020.1762852 – volume: 172 year: 2020 ident: B1 article-title: The Incubation Period of Coronavirus Disease 2019 (Covid-19) From Publicly Reported Confirmed Cases: Estimation and Application publication-title: Ann Intern Med doi: 10.7326/M20-0504 – volume: 19 year: 2013 ident: B29 article-title: Endothelial Vulnerability and Endothelial Damage Are Associated With Risk of Graft-Versus-Host Disease and Response to Steroid Treatment publication-title: Biol Blood Marrow Transplant doi: 10.1016/j.bbmt.2012.09.018 – volume: 148 start-page: e175 year: 2020 ident: B41 article-title: Risk Factors of Severe Cases With COVID-19: A Meta-Analysis publication-title: Epidemiol Infect doi: 10.1017/S095026882000179X – volume: 58 year: 2020 ident: B42 article-title: Lactate Dehydrogenase: An Old Enzyme Reborn as a COVID-19 Marker (and Not Only) publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2020-1062 – volume: 92 start-page: 95 year: 2020 ident: B22 article-title: Predicting Sinusoidal Obstruction Syndrome After Allogeneic Stem Cell Transplantation With the EASIX Biomarker Panel publication-title: Haematologica – volume: 50 year: 2008 ident: B36 article-title: The Performance of Risk Prediction Models publication-title: Biom J doi: 10.1002/bimj.200810443
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Snippet	The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges... BackgroundThe coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that...
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SubjectTerms	Adolescent Adult Aged Aged, 80 and over angiopoietin-2 (Ang-2) Biomarkers - metabolism COVID-19 - diagnosis COVID-19 - mortality EASIX endothelial activation and stress index Endothelial Cells - physiology Female Hematopoietic Stem Cell Transplantation Hospitalization Humans Immunology Male Middle Aged Prognosis Prospective Studies Respiration, Artificial SARS-CoV-2 - physiology SARS-CoV2 (COVID- 19) Severity of Illness Index soluble thrombomodulin suppressor of tumorigenicity 2 (ST2) Survival Analysis Transplantation, Homologous Treatment Outcome Young Adult
Title	EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients
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