Galectin-3 acts as an angiogenic switch to induce tumor angiogenesis via Jagged-1/Notch activation

Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that galectin-3 (gal-3), a glycan-binding protein secreted by cancer cells under hypoxic conditions, triggers sprouting angiogenesis, assisted by...

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Bibliographic Details
Published in:	Oncotarget Vol. 8; no. 30; p. 49484
Main Authors:	Dos Santos, Sofia Nascimento, Sheldon, Helen, Pereira, Jonathas Xavier, Paluch, Christopher, Bridges, Esther M, El-Cheikh, Márcia Curry, Harris, Adrian L, Bernardes, Emerson Soares
Format:	Journal Article
Language:	English
Published:	United States 25.07.2017
Subjects:	Animals Blood Proteins Disease Models, Animal Endothelial Cells - metabolism Galectin 3 - genetics Galectin 3 - metabolism Galectins Humans Hypoxia - metabolism Intracellular Signaling Peptides and Proteins - metabolism Jagged-1 Protein - metabolism Ligands Membrane Proteins - metabolism Mice Mice, Knockout Models, Biological Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Protein Binding Receptors, Notch - metabolism Signal Transduction cancer Jagged-1 galectin-3 angiogenesis Notch
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
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