The Molecular Basis of Spinocerebellar Ataxia Type 7

Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat expansion in the ataxin 7 ( ATXN7 ) gene, which results in polyglutamine expansion at the amino terminus of the ATXN7 protein. Although ATXN7 is expressed widely, the best characterized symptoms of SCA7 are remarkably...

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Vydané v:	Frontiers in neuroscience Ročník 16; s. 818757
Hlavní autori:	Goswami, Rituparna, Bello, Abudu I., Bean, Joe, Costanzo, Kara M., Omer, Bwaar, Cornelio-Parra, Dayanne, Odah, Revan, Ahluwalia, Amit, Allan, Shefaa K., Nguyen, Nghi, Shores, Taylor, Aziz, N. Ahmad, Mohan, Ryan D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland Frontiers Media S.A 24.03.2022
Predmet:	ATXN7 deubiquitination Neuroscience polyglutamine expansion SAGA complex USP22 deubiquitination ATXN7 polyglutamine expansion SAGA complex USP22
ISSN:	1662-453X, 1662-4548, 1662-453X
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