The Molecular Basis of Spinocerebellar Ataxia Type 7

Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat expansion in the ataxin 7 ( ATXN7 ) gene, which results in polyglutamine expansion at the amino terminus of the ATXN7 protein. Although ATXN7 is expressed widely, the best characterized symptoms of SCA7 are remarkably...

Full description

Bibliographic Details

Published in:	Frontiers in neuroscience Vol. 16; p. 818757
Main Authors:	Goswami, Rituparna, Bello, Abudu I., Bean, Joe, Costanzo, Kara M., Omer, Bwaar, Cornelio-Parra, Dayanne, Odah, Revan, Ahluwalia, Amit, Allan, Shefaa K., Nguyen, Nghi, Shores, Taylor, Aziz, N. Ahmad, Mohan, Ryan D.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 24.03.2022
Subjects:	ATXN7 deubiquitination Neuroscience polyglutamine expansion SAGA complex USP22 deubiquitination ATXN7 polyglutamine expansion SAGA complex USP22
ISSN:	1662-453X, 1662-4548, 1662-453X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!