Challenges for vaccination in the elderly
The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent...
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| Veröffentlicht in: | Immunity & ageing Jg. 4; H. 1; S. 9 |
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11.12.2007
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| Abstract | The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population. |
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| AbstractList | The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naive T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naive markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population. The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population. The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population.The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population. Abstract The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population. |
| ArticleNumber | 9 |
| Audience | Academic |
| Author | Del Giudice, Giuseppe Sambhara, Suryaprakash Effros, Rita B Grubeck-Loebenstein, Beatrix Aspinall, Richard |
| AuthorAffiliation | 5 Influenza Division, Centers for Disease Control and Prevention, Atlanta, USA 2 Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy 4 Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria 3 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, USA 1 Department of Immunology, Imperial College, London, UK |
| AuthorAffiliation_xml | – name: 2 Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy – name: 4 Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria – name: 1 Department of Immunology, Imperial College, London, UK – name: 3 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, USA – name: 5 Influenza Division, Centers for Disease Control and Prevention, Atlanta, USA |
| Author_xml | – sequence: 1 givenname: Richard surname: Aspinall fullname: Aspinall, Richard – sequence: 2 givenname: Giuseppe surname: Del Giudice fullname: Del Giudice, Giuseppe – sequence: 3 givenname: Rita B surname: Effros fullname: Effros, Rita B – sequence: 4 givenname: Beatrix surname: Grubeck-Loebenstein fullname: Grubeck-Loebenstein, Beatrix – sequence: 5 givenname: Suryaprakash surname: Sambhara fullname: Sambhara, Suryaprakash |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18072962$$D View this record in MEDLINE/PubMed |
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| Title | Challenges for vaccination in the elderly |
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