Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Tenosynovial giant cell tumour (TGCT) is a locally aggressive neoplasm for which few systemic treatment options exist. This study evaluated the efficacy and safety of vimseltinib, an oral, switch-control, CSF1R inhibitor, in patients with symptomatic TGCT not amenable to surgery. MOTION is a multice...

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Veröffentlicht in:	The Lancet (British edition) Jg. 403; H. 10445; S. 2709 - 2719
Hauptverfasser:	Gelderblom, Hans, Bhadri, Vivek, Stacchiotti, Silvia, Bauer, Sebastian, Wagner, Andrew J, van de Sande, Michiel, Bernthal, Nicholas M, López Pousa, Antonio, Razak, Albiruni Abdul, Italiano, Antoine, Ahmed, Mahbubl, Le Cesne, Axel, Tinoco, Gabriel, Boye, Kjetil, Martín-Broto, Javier, Palmerini, Emanuela, Tafuto, Salvatore, Pratap, Sarah, Powers, Benjamin C, Reichardt, Peter, Casado Herráez, Antonio, Rutkowski, Piotr, Tait, Christopher, Zarins, Fiona, Harrow, Brooke, Sharma, Maitreyi G, Ruiz-Soto, Rodrigo, Sherman, Matthew L, Blay, Jean-Yves, Tap, William D, Loong, Herbert, Brunello, Antonella, Krieg, Andreas, Algulnik, Mark, Riedel, Richard, Okuno, Scott, Loggers, Elizabeth, Alcindor, Thierry, Ferraresi, Virginia, Serrano, César, Randall, R. Lor, Wilky, Breelyn, Ravi, Vinod
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 22.06.2024 Elsevier Limited
Schlagworte:	Adult Aged Analgesics Anilides Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Clinical outcomes Creatine Creatine kinase Double-Blind Method Drug dosages Female Giant Cell Tumor of Tendon Sheath - drug therapy Health services Hepatotoxicity Humans Kinases Male Middle Aged Morbidity Narcotics Patients Placebos Quality of life Questionnaires Quinolines Range of motion Regulatory approval Response rates Solid tumors Statistical analysis Surgery Treatment Outcome Tumors United States > US
ISSN:	0140-6736, 1474-547X, 1474-547X
Online-Zugang:	Volltext
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