Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Vaccines (Basel) Ročník 9; číslo 8; s. 807
Hlavní autoři:	Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O’Connell, Kyle P., Lopes, Mikayla C., Rabinowitz, Benjamin A., Ghosh, Chandra C., Guha, Prajna, Jaroch, David, Cox, Bryan F., Katz, Steven C.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel MDPI AG 21.07.2021 MDPI
Témata:	Animal models Antibodies Anticancer properties Antitumor agents Apoptosis Biocompatibility Bioluminescence Catheters Colorectal carcinoma Flow cytometry Hepatocytes Immune checkpoint Laboratories Liver Liver cancer liver metastasis Melanoma Metastases Metastasis myeloid-derived suppressor cells PD-1 PD-1 protein PD-L1 PD-L1 protein Portal vein Proteins regional delivery Software Suppressor cells systemic delivery Toxicity Tumor cells Tumors Veins St Louis Missouri United States > US Germany
ISSN:	2076-393X, 2076-393X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!