Evaluation of Side Effects Associated with COVID-19 Vaccines in Saudi Arabia

Background: Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have been associated with these vaccines. Thus, we aimed to evaluate short-term post-vaccination side effects. Methods: Cross-section...

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Vydáno v:Vaccines (Basel) Ročník 9; číslo 6; s. 674
Hlavní autoři: Alhazmi, Abdulaziz, Alamer, Edrous, Daws, Dalia, Hakami, Mashael, Darraj, Majid, Abdelwahab, Siddig, Maghfuri, Amani, Algaissi, Abdullah
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 18.06.2021
MDPI
Témata:
Adenoviruses
Age
Chronic illnesses
Clinical trials
Coronaviruses
COVID-19
COVID-19 vaccines
Disease prevention
Drug dosages
Fatigue
FDA approval
Fever
Infections
mRNA vaccines
Pain
Pandemics
Population
Questionnaires
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Side effects
Social networks
vaccine
Vaccines
Saudi Arabia
United States > US
ISSN:2076-393X, 2076-393X
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Abstract Background: Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have been associated with these vaccines. Thus, we aimed to evaluate short-term post-vaccination side effects. Methods: Cross-sectional, retrospective study using an online questionnaire was conducted among COVID-19 vaccines recipients in Saudi Arabia. General and demographic data were collected, and vaccine-associated side effects after receiving at least one dose of each vaccine were evaluated. Results: Our final sample consisted of 515 participants with a median age of 26 years. Most of the study participants were female (57%). Nearly 13% of the study subjects have reported previous infections with SARS-CoV-2. Oxford-AstraZeneca and Pfizer-BioNTech vaccines have been received by 75% and 25% of the study participants, respectively. Side effects associated with COVID-19 vaccines have been reported by 60% of the study subjects, and most of them reported fatigue (90%), pain at the site of the injections (85%). Conclusion: Side effects that are reported post Oxford-AstraZeneca and Pfizer-BioNTech vaccines among our study participants are not different from those that were reported in the clinical trials, indicating safe profiles for both vaccines. Further studies are needed to evaluate the effectiveness of the current vaccines in protection against SARS-CoV-2 reinfections.
AbstractList Background: Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have been associated with these vaccines. Thus, we aimed to evaluate short-term post-vaccination side effects. Methods: Cross-sectional, retrospective study using an online questionnaire was conducted among COVID-19 vaccines recipients in Saudi Arabia. General and demographic data were collected, and vaccine-associated side effects after receiving at least one dose of each vaccine were evaluated. Results: Our final sample consisted of 515 participants with a median age of 26 years. Most of the study participants were female (57%). Nearly 13% of the study subjects have reported previous infections with SARS-CoV-2. Oxford-AstraZeneca and Pfizer-BioNTech vaccines have been received by 75% and 25% of the study participants, respectively. Side effects associated with COVID-19 vaccines have been reported by 60% of the study subjects, and most of them reported fatigue (90%), pain at the site of the injections (85%). Conclusion: Side effects that are reported post Oxford-AstraZeneca and Pfizer-BioNTech vaccines among our study participants are not different from those that were reported in the clinical trials, indicating safe profiles for both vaccines. Further studies are needed to evaluate the effectiveness of the current vaccines in protection against SARS-CoV-2 reinfections.
Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have been associated with these vaccines. Thus, we aimed to evaluate short-term post-vaccination side effects.BACKGROUNDPfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have been associated with these vaccines. Thus, we aimed to evaluate short-term post-vaccination side effects.Cross-sectional, retrospective study using an online questionnaire was conducted among COVID-19 vaccines recipients in Saudi Arabia. General and demographic data were collected, and vaccine-associated side effects after receiving at least one dose of each vaccine were evaluated.METHODSCross-sectional, retrospective study using an online questionnaire was conducted among COVID-19 vaccines recipients in Saudi Arabia. General and demographic data were collected, and vaccine-associated side effects after receiving at least one dose of each vaccine were evaluated.Our final sample consisted of 515 participants with a median age of 26 years. Most of the study participants were female (57%). Nearly 13% of the study subjects have reported previous infections with SARS-CoV-2. Oxford-AstraZeneca and Pfizer-BioNTech vaccines have been received by 75% and 25% of the study participants, respectively. Side effects associated with COVID-19 vaccines have been reported by 60% of the study subjects, and most of them reported fatigue (90%), pain at the site of the injections (85%).RESULTSOur final sample consisted of 515 participants with a median age of 26 years. Most of the study participants were female (57%). Nearly 13% of the study subjects have reported previous infections with SARS-CoV-2. Oxford-AstraZeneca and Pfizer-BioNTech vaccines have been received by 75% and 25% of the study participants, respectively. Side effects associated with COVID-19 vaccines have been reported by 60% of the study subjects, and most of them reported fatigue (90%), pain at the site of the injections (85%).Side effects that are reported post Oxford-AstraZeneca and Pfizer-BioNTech vaccines among our study participants are not different from those that were reported in the clinical trials, indicating safe profiles for both vaccines. Further studies are needed to evaluate the effectiveness of the current vaccines in protection against SARS-CoV-2 reinfections.CONCLUSIONSide effects that are reported post Oxford-AstraZeneca and Pfizer-BioNTech vaccines among our study participants are not different from those that were reported in the clinical trials, indicating safe profiles for both vaccines. Further studies are needed to evaluate the effectiveness of the current vaccines in protection against SARS-CoV-2 reinfections.
Author Abdelwahab, Siddig
Maghfuri, Amani
Alhazmi, Abdulaziz
Hakami, Mashael
Algaissi, Abdullah
Daws, Dalia
Alamer, Edrous
Darraj, Majid
AuthorAffiliation 4 Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
1 Department of Microbiology and Parasitology, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia; abalhazmi@jazanu.edu.sa
6 College of Medicine, Jazan University, Jazan 45142, Saudi Arabia; Amanimgf@gmail.com
5 Department of Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia; mdarraj@jazanu.edu.sa
2 Jazan University Hospital, Jazan University, Jazan 45142, Saudi Arabia; ddous@jazanu.edu.sa (D.D.); mashael@jazanu.edu.sa (M.H.)
3 Medical Research Center, Jazan University, Jazan 45142, Saudi Arabia; ealamer@jazanu.edu.sa (E.A.); sadiqa@jazanu.edu.sa (S.A.)
AuthorAffiliation_xml – name: 4 Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
– name: 1 Department of Microbiology and Parasitology, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia; abalhazmi@jazanu.edu.sa
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– name: 6 College of Medicine, Jazan University, Jazan 45142, Saudi Arabia; Amanimgf@gmail.com
– name: 5 Department of Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia; mdarraj@jazanu.edu.sa
– name: 3 Medical Research Center, Jazan University, Jazan 45142, Saudi Arabia; ealamer@jazanu.edu.sa (E.A.); sadiqa@jazanu.edu.sa (S.A.)
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Copyright 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 by the authors. 2021
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Snippet Background: Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side...
Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have...
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SubjectTerms Adenoviruses
Age
Chronic illnesses
Clinical trials
Coronaviruses
COVID-19
COVID-19 vaccines
Disease prevention
Drug dosages
Fatigue
FDA approval
Fever
Infections
mRNA vaccines
Pain
Pandemics
Population
Questionnaires
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Side effects
Social networks
vaccine
Vaccines
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Title Evaluation of Side Effects Associated with COVID-19 Vaccines in Saudi Arabia
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