Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects

Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of prostate cancers and is a promising marker for cancer detection. We sought to develop a test for prostate cancer based on a quantitative methylation-specific polymerase...

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Vydané v:	Journal of clinical oncology Ročník 23; číslo 27; s. 6569
Hlavní autori:	Hoque, Mohammad Obaidul, Topaloglu, Ozlem, Begum, Shahnaz, Henrique, Rui, Rosenbaum, Eli, Van Criekinge, Wim, Westra, William H, Sidransky, David
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 20.09.2005
Predmet:	Adult Aged Aged, 80 and over Biomarkers, Tumor - urine Case-Control Studies DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - urine Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor - physiology Humans Logistic Models Male Middle Aged Neoplasm Proteins - urine Polymerase Chain Reaction - methods Probability Promoter Regions, Genetic Prostatic Neoplasms - genetics Prostatic Neoplasms - surgery Prostatic Neoplasms - urine Reference Values Sensitivity and Specificity Urinalysis
ISSN:	0732-183X
On-line prístup:	Zistit podrobnosti o prístupe
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