Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

Neural injury leads to inflammation and activation of microglia that in turn may participate in progression of neurodegeneration. The mechanisms involved in changing microglial activity from beneficial to chronic detrimental neuroinflammation are not known but reactive oxygen species (ROS) may be in...

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Bibliographic Details
Published in:	Glia Vol. 58; no. 5; pp. 588 - 598
Main Authors:	Rojo, Ana I., Innamorato, Nadia G., Martín-Moreno, Ana M., De Ceballos, María L., Yamamoto, Masayuki, Cuadrado, Antonio
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2010
Subjects:	Analysis of Variance Animals Antigens, Differentiation - metabolism Brain - metabolism Brain - pathology Calcium-Binding Proteins - metabolism CD11b Antigen - metabolism Cell Line, Transformed Culture Media, Conditioned - pharmacology Cyclooxygenase 2 - metabolism Cytokines - metabolism Disease Models, Animal Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Flow Cytometry - methods Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glial Fibrillary Acidic Protein - metabolism Gliosis - etiology heme oxygenase-1 Inflammation - etiology Inflammation - metabolism innate immune system Leukocyte Common Antigens - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Microfilament Proteins Microglia - physiology MPTP Poisoning - complications MPTP Poisoning - pathology neurodegenerative diseases Neurons - chemistry Neurons - drug effects Neurons - metabolism NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - metabolism Nitric Oxide Synthase Type II - metabolism Reactive Oxygen Species - metabolism Tyrosine 3-Monooxygenase - metabolism
ISSN:	0894-1491, 1098-1136, 1098-1136
Online Access:	Get full text
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