Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels-Alder and...

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Bibliographic Details
Published in:	Angewandte Chemie (International ed.) Vol. 48; no. 28; pp. 5159 - 5162
Main Authors:	Coquière, David, Bos, Jeffrey, Beld, Joris, Roelfes, Gerard
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 29.06.2009 WILEY‐VCH Verlag Wiley
Subjects:	Amino Acid Sequence Animals artificial metalloenzymes asymmetric catalysis Catalysis Cattle Chemistry Chemistry, Multidisciplinary copper Copper - chemistry Diels–Alder reactions Metalloproteins - chemistry Michael addition Molecular Sequence Data Pancreatic Polypeptide - chemistry Physical Sciences Science & Technology Stereoisomerism Michael addition OXALOACETATE DECARBOXYLASE DESIGN ALPHA,BETA-UNSATURATED 2-ACYL IMIDAZOLES PROTEIN asymmetric catalysis DIRECTED EVOLUTION BIOTIN-AVIDIN PEPTIDE TRIFLATE COMPLEXES Diels-Alder reactions HYBRID CATALYSTS copper artificial metalloenzymes
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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