Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction

Summary Allogeneic individuals co‐exist during pregnancy in eutherian mammals. Maternal and fetal cells intermingle at the site of placental attachment in the uterus, where the arteries are remodeled to supply the fetus with oxygen and nutrients. This access by placental cells to the maternal supply...

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Bibliographic Details
Published in:	Immunological reviews Vol. 267; no. 1; pp. 283 - 297
Main Authors:	Moffett, Ashley, Colucci, Francesco
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.09.2015
Subjects:	birth weight Evolution, Molecular Female HLA HLA-C Antigens - genetics HLA-C Antigens - immunology Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism KIR Ligands placenta Polymorphism, Genetic - genetics Polymorphism, Genetic - immunology Pregnancy Receptors, KIR - genetics Receptors, KIR - immunology trophoblast Trophoblasts - immunology Trophoblasts - metabolism birth weight placenta HLA trophoblast KIR
ISSN:	0105-2896, 1600-065X, 1600-065X
Online Access:	Get full text
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