Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction

Summary Allogeneic individuals co‐exist during pregnancy in eutherian mammals. Maternal and fetal cells intermingle at the site of placental attachment in the uterus, where the arteries are remodeled to supply the fetus with oxygen and nutrients. This access by placental cells to the maternal supply...

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Veröffentlicht in:	Immunological reviews Jg. 267; H. 1; S. 283 - 297
Hauptverfasser:	Moffett, Ashley, Colucci, Francesco
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.09.2015
Schlagworte:	birth weight Evolution, Molecular Female HLA HLA-C Antigens - genetics HLA-C Antigens - immunology Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism KIR Ligands placenta Polymorphism, Genetic - genetics Polymorphism, Genetic - immunology Pregnancy Receptors, KIR - genetics Receptors, KIR - immunology trophoblast Trophoblasts - immunology Trophoblasts - metabolism birth weight placenta HLA trophoblast KIR
ISSN:	0105-2896, 1600-065X, 1600-065X
Online-Zugang:	Volltext
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