Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association

Diagnostic and therapeutic advances during the past decades have substantially improved health outcomes for patients with acute coronary syndrome. Both age-related physiological changes and accumulated cardiovascular risk factors increase the susceptibility to acute coronary syndrome over a lifetime...

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Vydáno v:	Circulation (New York, N.Y.) Ročník 147; číslo 3; s. e32
Hlavní autoři:	Damluji, Abdulla A, Forman, Daniel E, Wang, Tracy Y, Chikwe, Joanna, Kunadian, Vijay, Rich, Michael W, Young, Bessie A, Page, 2nd, Robert L, DeVon, Holli A, Alexander, Karen P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 17.01.2023
Témata:	Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - epidemiology Acute Coronary Syndrome - therapy Aged American Heart Association Humans Prognosis Risk Assessment Risk Factors United States - epidemiology United States frailty acute coronary syndrome multimorbidity geriatric assessment cardiovascular diseases polypharmacy AHA Scientific Statements
ISSN:	1524-4539, 1524-4539
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Abstract	Diagnostic and therapeutic advances during the past decades have substantially improved health outcomes for patients with acute coronary syndrome. Both age-related physiological changes and accumulated cardiovascular risk factors increase the susceptibility to acute coronary syndrome over a lifetime. Compared with younger patients, outcomes for acute coronary syndrome in the large and growing demographic of older adults are relatively worse. Increased atherosclerotic plaque burden and complexity of anatomic disease, compounded by age-related cardiovascular and noncardiovascular comorbid conditions, contribute to the worse prognosis observed in older individuals. Geriatric syndromes, including frailty, multimorbidity, impaired cognitive and physical function, polypharmacy, and other complexities of care, can undermine the therapeutic efficacy of guidelines-based treatments and the resiliency of older adults to survive and recover, as well. In this American Heart Association scientific statement, we (1) review age-related physiological changes that predispose to acute coronary syndrome and management complexity; (2) describe the influence of commonly encountered geriatric syndromes on cardiovascular disease outcomes; and (3) recommend age-appropriate and guideline-concordant revascularization and acute coronary syndrome management strategies, including transitions of care, the use of cardiac rehabilitation, palliative care services, and holistic approaches. The primacy of individualized risk assessment and patient-centered care decision-making is highlighted throughout.
AbstractList	Diagnostic and therapeutic advances during the past decades have substantially improved health outcomes for patients with acute coronary syndrome. Both age-related physiological changes and accumulated cardiovascular risk factors increase the susceptibility to acute coronary syndrome over a lifetime. Compared with younger patients, outcomes for acute coronary syndrome in the large and growing demographic of older adults are relatively worse. Increased atherosclerotic plaque burden and complexity of anatomic disease, compounded by age-related cardiovascular and noncardiovascular comorbid conditions, contribute to the worse prognosis observed in older individuals. Geriatric syndromes, including frailty, multimorbidity, impaired cognitive and physical function, polypharmacy, and other complexities of care, can undermine the therapeutic efficacy of guidelines-based treatments and the resiliency of older adults to survive and recover, as well. In this American Heart Association scientific statement, we (1) review age-related physiological changes that predispose to acute coronary syndrome and management complexity; (2) describe the influence of commonly encountered geriatric syndromes on cardiovascular disease outcomes; and (3) recommend age-appropriate and guideline-concordant revascularization and acute coronary syndrome management strategies, including transitions of care, the use of cardiac rehabilitation, palliative care services, and holistic approaches. The primacy of individualized risk assessment and patient-centered care decision-making is highlighted throughout. Diagnostic and therapeutic advances during the past decades have substantially improved health outcomes for patients with acute coronary syndrome. Both age-related physiological changes and accumulated cardiovascular risk factors increase the susceptibility to acute coronary syndrome over a lifetime. Compared with younger patients, outcomes for acute coronary syndrome in the large and growing demographic of older adults are relatively worse. Increased atherosclerotic plaque burden and complexity of anatomic disease, compounded by age-related cardiovascular and noncardiovascular comorbid conditions, contribute to the worse prognosis observed in older individuals. Geriatric syndromes, including frailty, multimorbidity, impaired cognitive and physical function, polypharmacy, and other complexities of care, can undermine the therapeutic efficacy of guidelines-based treatments and the resiliency of older adults to survive and recover, as well. In this American Heart Association scientific statement, we (1) review age-related physiological changes that predispose to acute coronary syndrome and management complexity; (2) describe the influence of commonly encountered geriatric syndromes on cardiovascular disease outcomes; and (3) recommend age-appropriate and guideline-concordant revascularization and acute coronary syndrome management strategies, including transitions of care, the use of cardiac rehabilitation, palliative care services, and holistic approaches. The primacy of individualized risk assessment and patient-centered care decision-making is highlighted throughout.Diagnostic and therapeutic advances during the past decades have substantially improved health outcomes for patients with acute coronary syndrome. Both age-related physiological changes and accumulated cardiovascular risk factors increase the susceptibility to acute coronary syndrome over a lifetime. Compared with younger patients, outcomes for acute coronary syndrome in the large and growing demographic of older adults are relatively worse. Increased atherosclerotic plaque burden and complexity of anatomic disease, compounded by age-related cardiovascular and noncardiovascular comorbid conditions, contribute to the worse prognosis observed in older individuals. Geriatric syndromes, including frailty, multimorbidity, impaired cognitive and physical function, polypharmacy, and other complexities of care, can undermine the therapeutic efficacy of guidelines-based treatments and the resiliency of older adults to survive and recover, as well. In this American Heart Association scientific statement, we (1) review age-related physiological changes that predispose to acute coronary syndrome and management complexity; (2) describe the influence of commonly encountered geriatric syndromes on cardiovascular disease outcomes; and (3) recommend age-appropriate and guideline-concordant revascularization and acute coronary syndrome management strategies, including transitions of care, the use of cardiac rehabilitation, palliative care services, and holistic approaches. The primacy of individualized risk assessment and patient-centered care decision-making is highlighted throughout.
Author	Wang, Tracy Y DeVon, Holli A Forman, Daniel E Rich, Michael W Chikwe, Joanna Alexander, Karen P Damluji, Abdulla A Page, 2nd, Robert L Kunadian, Vijay Young, Bessie A
Author_xml	– sequence: 1 givenname: Abdulla A surname: Damluji fullname: Damluji, Abdulla A – sequence: 2 givenname: Daniel E surname: Forman fullname: Forman, Daniel E – sequence: 3 givenname: Tracy Y surname: Wang fullname: Wang, Tracy Y – sequence: 4 givenname: Joanna surname: Chikwe fullname: Chikwe, Joanna – sequence: 5 givenname: Vijay surname: Kunadian fullname: Kunadian, Vijay – sequence: 6 givenname: Michael W surname: Rich fullname: Rich, Michael W – sequence: 7 givenname: Bessie A surname: Young fullname: Young, Bessie A – sequence: 8 givenname: Robert L surname: Page, 2nd fullname: Page, 2nd, Robert L – sequence: 9 givenname: Holli A surname: DeVon fullname: DeVon, Holli A – sequence: 10 givenname: Karen P surname: Alexander fullname: Alexander, Karen P
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36503287$$D View this record in MEDLINE/PubMed
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SubjectTerms	Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - epidemiology Acute Coronary Syndrome - therapy Aged American Heart Association Humans Prognosis Risk Assessment Risk Factors United States - epidemiology
Title	Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association
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