NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation

BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species production. NADPH oxidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothelium, yet its specific role...

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Veröffentlicht in:	Circulation (New York, N.Y.) Jg. 124; H. 6; S. 731
Hauptverfasser:	Craige, Siobhan M, Chen, Kai, Pei, Yongmei, Li, Chunying, Huang, Xiaoyun, Chen, Christine, Shibata, Rei, Sato, Kaori, Walsh, Kenneth, Keaney, Jr, John F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 09.08.2011
Schlagworte:	Animals Cattle Cell Hypoxia - genetics Cells, Cultured - enzymology Cyclic GMP - metabolism Endothelial Cells - enzymology Enzyme Induction Genetic Therapy Genetic Vectors - administration & dosage Genetic Vectors - therapeutic use Hindlimb - blood supply Humans Ischemia - therapy Mice Mice, Transgenic NADPH Oxidase 4 NADPH Oxidases - biosynthesis NADPH Oxidases - genetics NADPH Oxidases - physiology Neovascularization, Physiologic - physiology Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Nitric Oxide Synthase Type III - physiology Reactive Oxygen Species Recombinant Fusion Proteins - physiology RNA Interference RNA, Small Interfering - pharmacology
ISSN:	1524-4539, 1524-4539
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