A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis

•A role for neuronal connexin 36 in the pathogenesis of ALS is proposed.•The mechanism relies on contribution of connexin 36 to ALS-related neuronal death.•A perspective for the use of connexin 36 blockade for ALS therapy is discussed. Neuronal gap junctional protein connexin 36 (Cx36) contributes t...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 666; pp. 1 - 4
Main Authors:	Belousov, Andrei B., Nishimune, Hiroshi, Denisova, Janna V., Fontes, Joseph D.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 14.02.2018
Subjects:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Connexin 36 Connexins - metabolism Disease Models, Animal Gap Junction delta-2 Protein Gap junctions Gap Junctions - metabolism Humans Mice Motor Neurons - metabolism Neurodegenerative diseases Spinal cord Spinal Cord - metabolism Superoxide Dismutase-1 - metabolism Amyotrophic lateral sclerosis Spinal cord Neurodegenerative diseases Gap junctions Connexin 36
ISSN:	0304-3940, 1872-7972, 1872-7972
Online Access:	Get full text
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