Mechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance

Excess free fatty acids, an imbalance of adipocytokines and mitochondrial dysfunction all contribute to abnormalities in hepatocellular lipid content in diabetes and can lead to steatosis and insulin resistance. Thus liver fat is a novel target for therapies such as fat-reduced diets and thiazoliden...

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Bibliographic Details
Published in:	Nature clinical practice. Endocrinology & metabolism Vol. 2; no. 6; pp. 335 - 348
Main Author:	Roden, Michael
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.06.2006 Nature Publishing Group
Subjects:	Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Endocrinology Fatty acids Fatty Acids, Nonesterified - metabolism Fatty Liver - drug therapy Fatty Liver - etiology Fatty Liver - metabolism Gastroenterology Glucose Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin resistance Insulin Resistance - physiology Kinases Lipids Liver - drug effects Liver - metabolism Liver - pathology Liver cirrhosis Liver diseases Medicine Medicine & Public Health Metabolism Models, Biological Nephrology Nutrients Oils & fats review-article Triglycerides
ISSN:	1745-8366, 1759-5029, 1745-8374, 1759-5037
Online Access:	Get full text
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