Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function

Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy in the treatment of various diseases and is approved for treating hematological malignancies. Harnessing the therapeutic potential of HDACi...

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Vydané v:	Blood Ročník 121; číslo 11; s. 2038
Hlavní autori:	Heideman, Marinus R, Wilting, Roel H, Yanover, Eva, Velds, Arno, de Jong, Johann, Kerkhoven, Ron M, Jacobs, Heinz, Wessels, Lodewyk F, Dannenberg, Jan-Hermen
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 14.03.2013
Predmet:	Animals Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cells, Cultured Epistasis, Genetic - physiology Gene Dosage - genetics Gene Dosage - physiology Gene Expression Regulation - genetics Gene Expression Regulation - physiology Genes - physiology Genes, Tumor Suppressor - physiology Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylase 1 - physiology Histone Deacetylase 2 - genetics Histone Deacetylase 2 - metabolism Histone Deacetylase 2 - physiology Lymphoma - genetics Lymphoma - pathology Mice Mice, Inbred C57BL Mice, Transgenic Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins c-myc - physiology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology
ISSN:	1528-0020, 1528-0020
On-line prístup:	Zistit podrobnosti o prístupe
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