Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis

Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I interferons in response to pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying cells or in neutrophil ext...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 125; no. 13; p. 1673
Main Authors:	Döring, Yvonne, Manthey, Helga D, Drechsler, Maik, Lievens, Dirk, Megens, Remco T A, Soehnlein, Oliver, Busch, Martin, Manca, Marco, Koenen, Rory R, Pelisek, Jaroslav, Daemen, Mat J, Lutgens, Esther, Zenke, Martin, Binder, Christoph J, Weber, Christian, Zernecke, Alma
Format:	Journal Article
Language:	English
Published:	United States 03.04.2012
Subjects:	Animals Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - metabolism Autoantigens - genetics Autoantigens - immunology Carotid Stenosis - genetics Carotid Stenosis - immunology Carotid Stenosis - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism DNA - genetics DNA - immunology Female Humans Mice Mice, Inbred C57BL Mice, Knockout Proteins - genetics Proteins - immunology
ISSN:	1524-4539, 1524-4539
Online Access:	Get more information
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