Nedd4 controls animal growth by regulating IGF-1 signaling

The ubiquitin ligase Nedd4 has been proposed to regulate a number of signaling pathways, but its physiological role in mammals has not been characterized. Here we present an analysis of Nedd4-null mice to show that loss of Nedd4 results in reduced insulin-like growth factor 1 (IGF-1) and insulin sig...

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Bibliographic Details

Published in:	Science signaling Vol. 1; no. 38; p. ra5
Main Authors:	Cao, Xiao R, Lill, Nancy L, Boase, Natasha, Shi, Peijun P, Croucher, David R, Shan, Hongbo, Qu, Jing, Sweezer, Eileen M, Place, Trenton, Kirby, Patricia A, Daly, Roger J, Kumar, Sharad, Yang, Baoli
Format:	Journal Article
Language:	English
Published:	United States 23.09.2008
Subjects:	Animals Cell Membrane - metabolism Cells, Cultured Endosomal Sorting Complexes Required for Transport GRB10 Adaptor Protein - metabolism Insulin - physiology Insulin-Like Growth Factor I - physiology Mice Mice, Mutant Strains Nedd4 Ubiquitin Protein Ligases Phosphorylation Receptor, IGF Type 1 - metabolism Signal Transduction Ubiquitin-Protein Ligases - physiology
ISSN:	1937-9145, 1937-9145
Online Access:	Get more information
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