β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME

Myeloid-derived suppressor cells (MDSCs) impede antitumor immunity; however, the precise mechanisms that regulate their suppressive function remain unresolved. Identifying these mechanisms could lead to therapeutic interventions to boost cancer immunotherapy efficacy. Here, we reveal that β2 adrener...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 37; H. 4; S. 109883
Hauptverfasser:	Mohammadpour, Hemn, MacDonald, Cameron R., McCarthy, Philip L., Abrams, Scott I., Repasky, Elizabeth A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.10.2021
Schlagworte:	Animals autophagy cancer fatty acid oxidation immune suppression Lipid Metabolism - genetics Lipid Metabolism - immunology MDSCs metabolism Mice Mice, Knockout Myeloid-Derived Suppressor Cells - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplasms - genetics Neoplasms - immunology Oxidative Phosphorylation prostaglandin E2 Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - immunology Signal Transduction - immunology stress Tumor Microenvironment - genetics Tumor Microenvironment - immunology β-adrenergic signaling stress MDSCs autophagy prostaglandin E2 cancer metabolism β-adrenergic signaling fatty acid oxidation immune suppression oxidative phosphorylation
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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