Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mild memory symptoms in older humans. Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are t...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 108; číslo 14; s. 5819
Hlavní autori:	Jin, Ming, Shepardson, Nina, Yang, Ting, Chen, Gang, Walsh, Dominic, Selkoe, Dennis J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 05.04.2011
Predmet:	Alzheimer Disease - physiopathology Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Animals Blotting, Western Chromatography, Gel Dimerization Genetic Vectors - genetics Hippocampus - cytology Humans Immunohistochemistry Immunoprecipitation In Situ Nick-End Labeling Lentivirus Microscopy, Confocal Microtubules - drug effects Neurites - drug effects Neurites - pathology Phosphorylation - drug effects Rats Rats, Sprague-Dawley tau Proteins - metabolism
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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