Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA

After treatment of the human ovarian carcinoma cell line, CH1, with cisplatin, cells detached from the culture dish in a time- and dose-dependent fashion. These cells showed morphological changes indicative of apoptosis. Their DNA had not been degraded into oligonucleosomal fragments, but the DNA ha...

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Bibliographic Details
Published in:	Experimental cell research Vol. 211; no. 2; p. 231
Main Authors:	Ormerod, M G, O'Neill, C F, Robertson, D, Harrap, K R
Format:	Journal Article
Language:	English
Published:	United States 01.04.1994
Subjects:	Apoptosis - drug effects Apoptosis - physiology Cell Adhesion - drug effects Cisplatin - pharmacology DNA, Neoplasm - chemistry DNA, Neoplasm - metabolism Female Humans Microscopy, Electron Molecular Weight Nucleosomes - drug effects Nucleosomes - metabolism Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology
ISSN:	0014-4827
Online Access:	Get more information
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