Immunoregulatory Role of MicroRNA-21 in Macrophages in Response to Bacillus Calmette-Guerin Infection Involves Modulation of the TLR4/MyD88 Signaling Pathway

Background/Aims: The purpose of this study is to explore the immunoregulatory role of microRNA-21 (miR-21) targeting of the TLR4/MyD88 signaling pathway in macrophages in response to Bacillus Calmette-Guerin (BCG) infection. Methods: After infection with BCG, mouse RAW246.7 cells were assigned into...

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Bibliographic Details
Published in:	Cellular physiology and biochemistry Vol. 42; no. 1; pp. 91 - 102
Main Authors:	Xue, Xin, Qiu, Yi, Yang, Hong-Li
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland S. Karger AG 01.01.2017 Cell Physiol Biochem Press GmbH & Co KG
Subjects:	Animals Antagomirs - metabolism Apoptosis Bacilli Calmette-Guerin Base Sequence Biological products Cancer Cardiovascular disease Enzyme-Linked Immunosorbent Assay Gene expression Infections Interleukin-10 - analysis Interleukin-6 - analysis Laboratories Leukemia Macrophage Mice MicroRNA-21 MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Microscopy, Electron, Transmission Mycobacterium bovis - physiology Myeloid differentiation factor 88 Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Pathogens Proteins RAW 264.7 Cells Retracted Paper RNA, Messenger - metabolism Sequence Alignment Signal Transduction - drug effects Signaling pathway Stem cells Sulfonamides - pharmacology Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors 4 Tuberculosis Tumor Necrosis Factor-alpha - analysis United States > US China Utah Myeloid differentiation factor 88 MicroRNA-21 Signaling pathway Toll-like receptors 4 Bacilli Calmette-Guerin Macrophage
ISSN:	1015-8987, 1421-9778, 1421-9778
Online Access:	Get full text
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